SCORE Operational Research on Moving toward Interruption of Schistosomiasis Transmission.

Autor:	Campbell CH; 1Schistosomiasis Consortium for Operational Research and Evaluation, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia., Binder S; 1Schistosomiasis Consortium for Operational Research and Evaluation, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia., King CH; 1Schistosomiasis Consortium for Operational Research and Evaluation, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia.; 2Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio., Knopp S; 3Swiss Tropical and Public Health Institute, Basel, Switzerland.; 4University of Basel, Basel, Switzerland.; 5Department of Life Sciences, Wolfson Wellcome Biomedical Laboratories, Natural History Museum, London, United Kingdom., Rollinson D; 5Department of Life Sciences, Wolfson Wellcome Biomedical Laboratories, Natural History Museum, London, United Kingdom.; 6London Centre for Neglected Tropical Disease Research, Imperial College Faculty of Medicine, London, United Kingdom., Person B; 1Schistosomiasis Consortium for Operational Research and Evaluation, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia., Webster B; 5Department of Life Sciences, Wolfson Wellcome Biomedical Laboratories, Natural History Museum, London, United Kingdom.; 6London Centre for Neglected Tropical Disease Research, Imperial College Faculty of Medicine, London, United Kingdom., Allan F; 5Department of Life Sciences, Wolfson Wellcome Biomedical Laboratories, Natural History Museum, London, United Kingdom.; 6London Centre for Neglected Tropical Disease Research, Imperial College Faculty of Medicine, London, United Kingdom., Utzinger J; 3Swiss Tropical and Public Health Institute, Basel, Switzerland.; 4University of Basel, Basel, Switzerland., Ame SM; 7Public Health Laboratory - Ivo de Carneri, Pemba, United Republic of Tanzania., Ali SM; 7Public Health Laboratory - Ivo de Carneri, Pemba, United Republic of Tanzania., Kabole F; 8Neglected Tropical Diseases Unit, Ministry of Health Zanzibar, Unguja, United Republic of Tanzania., N'Goran EK; 9Centre Suisse de Recherches Scientifiques en Côte d'Ivoire, Abidjan, Côte d'Ivoire.; 10Unité de Formation et de Recherche Biosciences, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire., Tediosi F; 3Swiss Tropical and Public Health Institute, Basel, Switzerland.; 4University of Basel, Basel, Switzerland., Salari P; 3Swiss Tropical and Public Health Institute, Basel, Switzerland.; 4University of Basel, Basel, Switzerland., Ouattara M; 9Centre Suisse de Recherches Scientifiques en Côte d'Ivoire, Abidjan, Côte d'Ivoire.; 10Unité de Formation et de Recherche Biosciences, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire., Diakité NR; 9Centre Suisse de Recherches Scientifiques en Côte d'Ivoire, Abidjan, Côte d'Ivoire.; 10Unité de Formation et de Recherche Biosciences, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire., Hattendorf J; 3Swiss Tropical and Public Health Institute, Basel, Switzerland.; 4University of Basel, Basel, Switzerland., S Andros T; 1Schistosomiasis Consortium for Operational Research and Evaluation, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia., Kittur N; 1Schistosomiasis Consortium for Operational Research and Evaluation, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia., Colley DG; 1Schistosomiasis Consortium for Operational Research and Evaluation, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia.; 11Department of Microbiology, University of Georgia, Athens, Georgia.
Jazyk:	angličtina
Zdroj:	The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2020 Jul; Vol. 103 (1_Suppl), pp. 58-65.
DOI:	10.4269/ajtmh.19-0825
Abstrakt:	As part of its diverse portfolio, the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) included two cluster-randomized trials evaluating interventions that could potentially lead to interruption of schistosomiasis transmission (elimination) in areas of Africa with low prevalence and intensity of infection. These studies, conducted in Zanzibar and Côte d'Ivoire, demonstrated that multiyear mass drug administration (MDA) with praziquantel failed to interrupt the transmission of urogenital schistosomiasis, even when provided biannually and/or supplemented by small-scale implementation of additional interventions. Other SCORE activities related to elimination included a feasibility and acceptability assessment of test-treat-track-test-treat (T5) strategies and mathematical modeling. Future evaluations of interventions to eliminate schistosomiasis should recognize the difficulties inherent in conducting randomized controlled trials on elimination and in measuring small changes where baseline prevalence is low. Highly sensitive and specific diagnostic tests for use in very low-prevalence areas for schistosomiasis are not routinely available, which complicates accurate measurement of infection rates and assessment of changes resulting from interventions in these settings. Although not encountered in these two studies, as prevalence and intensity decrease, political and community commitment to population-wide MDA may decrease. Because of this potential problem, SCORE developed and funded the T5 strategy implemented in Egypt, Kenya, and Tanzania. It is likely that focal MDA campaigns, along with more targeted approaches, including a T5 strategy and snail control, will need to be supplemented with the provision of clean water and sanitation and behavior change communications to achieve interruption of schistosome transmission.
Databáze:	MEDLINE
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