Human Microcirculation-on-Chip Models in Cancer Research: Key Integration of Lymphatic and Blood Vasculatures.

Autor: Luque-González MA; 3B's Research Group, I3Bs-Research Institute on Biomaterials Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, ICVS/3B's-PT Government Associate Laboratory, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra 4805-017 Barco, Braga/Guimarães, Portugal., Reis RL; 3B's Research Group, I3Bs-Research Institute on Biomaterials Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, ICVS/3B's-PT Government Associate Laboratory, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra 4805-017 Barco, Braga/Guimarães, Portugal., Kundu SC; 3B's Research Group, I3Bs-Research Institute on Biomaterials Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, ICVS/3B's-PT Government Associate Laboratory, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra 4805-017 Barco, Braga/Guimarães, Portugal., Caballero D; 3B's Research Group, I3Bs-Research Institute on Biomaterials Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, ICVS/3B's-PT Government Associate Laboratory, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra 4805-017 Barco, Braga/Guimarães, Portugal.
Jazyk: angličtina
Zdroj: Advanced biosystems [Adv Biosyst] 2020 Jul; Vol. 4 (7), pp. e2000045. Date of Electronic Publication: 2020 May 12.
DOI: 10.1002/adbi.202000045
Abstrakt: Cancer metastasis is a highly complex and multistep process, which is initiated by the invasion of tumor cells into the microcirculation system. A diverse variety of organ-on-chip models are described investigating this critical event. However, most of these models solely integrate the blood vasculature and overlook the fundamental role of the lymphatic system despite the solid evidence showing that cancer cells mainly use this vascular network to initiate metastasis. Herein, the latest advances in the field of organ-on-chip models of the human microcirculation system in cancer research are reviewed. The reported models are employed to investigate the mechanistic determinants of tumor physiopathology and for the screening of new anticancer drugs under the scope of the microcirculation bed. Overall, the development of complete microcirculation-on-chip models integrating the blood and lymphatic vasculatures is expected to provide key insights into the drug delivery process, the screening of novel therapeutic compounds, or the mechanism of tumor invasion and metastasis, among others.
(© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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