| Autor: |
Özkan A; Department of Mechanical Engineering, The University of Texas, Austin, TX 78712, USA., Stolley D; Department of Biomedical Engineering, The University of Texas, Austin, TX 78712, USA., Cressman ENK; Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., McMillin M; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX 78713, USA.; Central Texas Veterans Health Care System, Temple, TX 76504, USA., DeMorrow S; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX 78713, USA.; Central Texas Veterans Health Care System, Temple, TX 76504, USA.; Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA., Yankeelov TE; Department of Biomedical Engineering, The University of Texas, Austin, TX 78712, USA.; Oden Institute for Computational Engineering and Sciences, The University of Texas, Austin, TX 78712, USA.; Departments of Diagnostic Medicine, The University of Texas, Austin, TX 78712, USA.; Department of Oncology, The University of Texas, Austin, TX 78712, USA.; Livestrong Cancer Institutes, Dell Medical School, The University of Texas, Austin, TX 78712, USA., Rylander MN; Department of Mechanical Engineering, The University of Texas, Austin, TX 78712, USA.; Department of Biomedical Engineering, The University of Texas, Austin, TX 78712, USA.; Oden Institute for Computational Engineering and Sciences, The University of Texas, Austin, TX 78712, USA. |
| Abstrakt: |
In chronic liver diseases and hepatocellular carcinoma, the cells and extracellular matrix of the liver undergo significant alteration in response to chronic injury. Recent literature has highlighted the critical, but less studied, role of the liver vasculature in the progression of chronic liver diseases. Recent advancements in liver-on-a-chip systems has allowed in depth investigation of the role that the hepatic vasculature plays both in response to, and progression of, chronic liver disease. In this review, we first introduce the structure, gradients, mechanical properties, and cellular composition of the liver and describe how these factors influence the vasculature. We summarize state-of-the-art vascularized liver-on-a-chip platforms for investigating biological models of chronic liver disease and their influence on the liver sinusoidal endothelial cells of the hepatic vasculature. We conclude with a discussion of how future developments in the field may affect the study of chronic liver diseases, and drug development and testing. |
