Protective actions of exercise-related FNDC5/Irisin in memory and Alzheimer's disease.

Autor: de Freitas GB; Centre for Neuroscience Studies & Department of Psychiatry, Queen's University, Kingston, ON, Canada.; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Lourenco MV; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., De Felice FG; Centre for Neuroscience Studies & Department of Psychiatry, Queen's University, Kingston, ON, Canada.; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Jazyk: angličtina
Zdroj: Journal of neurochemistry [J Neurochem] 2020 Dec; Vol. 155 (6), pp. 602-611. Date of Electronic Publication: 2020 Jun 02.
DOI: 10.1111/jnc.15039
Abstrakt: The proportion of elderly populations is rapidly booming, and human lifespan has considerably increased in the past century because of scientific and medical advances. However, the winds of change brought by the 21st century made sedentarism one of the factors that renders the brain vulnerable to age-related chronic diseases, such as Alzheimer's disease (AD). Conversely, physical exercise has been shown to stimulate molecular mechanisms beneficial to cognition. Here, we review evidence showing the positive effects of physical exercise in the brain. We further discuss recent evidence that irisin, a myokine stimulated by physical exercise derived from fibronectin type III domain-containing protein 5 (FNDC5) transmembrane protein, has neuroprotective actions in the brain. Lastly, we highlight the importance of the crosstalk between the periphery and the brain in cognition and the therapeutic potential of FNDC5/irisin in AD.
(© 2020 International Society for Neurochemistry.)
Databáze: MEDLINE
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