Mean platelet counts are relatively decreased with malaria but relatively increased with endemic Burkitt Lymphoma in Uganda, Tanzania, and Kenya.

Autor: Peprah S; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Ogwang MD; EpideMiology of Burkitt Lymphoma in East African Children and Minors Study, St. Mary's Hospital, Lacor, Gulu & African Field Epidemiology Network, Kampala, Uganda., Kerchan P; EpideMiology of Burkitt Lymphoma in East African Children and Minors Study, Kuluva Hospital, Arua & African Field Epidemiology Network, Kuluva, Kampala, Uganda., Reynolds SJ; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Tenge CN; EpideMiology of Burkitt Lymphoma in East African Children and Minors Study, Moi University College of Health Sciences, Eldoret, Kenya., Were PA; EpideMiology of Burkitt Lymphoma in East African Children and Minors Study, Academic Model Providing Access To Healthcare, Eldoret, Kenya., Kuremu RT; EpideMiology of Burkitt Lymphoma in East African Children and Minors Study, Moi University College of Health Sciences, Eldoret, Kenya., Wekesa WN; EpideMiology of Burkitt Lymphoma in East African Children and Minors Study, Moi University College of Health Sciences, Eldoret, Kenya., Masalu N; EpideMiology of Burkitt Lymphoma in East African Children and Minors Study, Bugando Medical Center, Mwanza, Tanzania., Kawira E; EpideMiology of Burkitt Lymphoma in East African Children and Minors Study, Shirati Health, Education, and Development Foundation, and Shirati Hospital, Shirati, Tanzania., Kinyera T; EpideMiology of Burkitt Lymphoma in East African Children and Minors Study, St. Mary's Hospital, Lacor, Gulu & African Field Epidemiology Network, Kampala, Uganda., Otim I; EpideMiology of Burkitt Lymphoma in East African Children and Minors Study, St. Mary's Hospital, Lacor, Gulu & African Field Epidemiology Network, Kampala, Uganda., Legason ID; EpideMiology of Burkitt Lymphoma in East African Children and Minors Study, Kuluva Hospital, Arua & African Field Epidemiology Network, Kuluva, Kampala, Uganda., Nabalende H; EpideMiology of Burkitt Lymphoma in East African Children and Minors Study, St. Mary's Hospital, Lacor, Gulu & African Field Epidemiology Network, Kampala, Uganda., Dhudha H; EpideMiology of Burkitt Lymphoma in East African Children and Minors Study, Shirati Health, Education, and Development Foundation, and Shirati Hospital, Shirati, Tanzania., Mumia M; EpideMiology of Burkitt Lymphoma in East African Children and Minors Study, Academic Model Providing Access To Healthcare, Eldoret, Kenya., Ayers LW; Department of Pathology, The Ohio State University, Columbus, OH, USA., Biggar RJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Bhatia K; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Goedert JJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Mbulaiteye SM; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Jazyk: angličtina
Zdroj: British journal of haematology [Br J Haematol] 2020 Sep; Vol. 190 (5), pp. 772-782. Date of Electronic Publication: 2020 May 12.
DOI: 10.1111/bjh.16700
Abstrakt: Platelet counts are decreased in Plasmodium falciparum malaria, which is aetiologically linked with endemic Burkitt lymphoma (eBL). However, the pattern of platelet counts in eBL cases is unknown. We studied platelet counts in 582 eBL cases and 2 248 controls enrolled in a case-control study in Uganda, Tanzania and Kenya (2010-2016). Mean platelet counts in controls or eBL cases with or without malaria-infection in controls versus eBLcases were compared using Student's t-test. Odds ratios (ORs) and two-sided 95% confidence intervals (95% CIs) were estimated using multiple logistic regression, controlling for age, sex, haemoglobin and white blood cell counts. Platelets were decreased with malaria infection in the controls [263 vs. 339 × 10 9 platelets/l, P < 0·0001; adjusted OR (aOR) = 3·42, 95% CI: 2·79-4·18] and eBL cases (314 vs. 367 × 10 9 platelets/l, P-value = 0·002; aOR = 2·36, 95% CI: 1·49-3·73). Unexpectedly, platelets were elevated in eBL cases versus  controls in overall analyses (mean: 353 vs. 307 × 10 9 platelets/l, P < 0·0001; aOR = 1·41; 95% CI: 1·12-1·77), and when restricted to malaria-positive (mean 314 vs. 263 × 10 9 platelets/l, P < 0·0001; OR = 2·26; 95% CI: 1·56-3·27) or malaria-negative (mean 367 vs. 339 × 10 9 platelets/l, P < 0·001; OR = 1·46; 95% CI: 1·17-1·83) subjects. Platelets were decreased with malaria infection in controls and eBL cases but elevated with eBL.
(© 2020 British Society for Haematology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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