Use of Corticosteroids in Coronavirus Disease 2019 Pneumonia: A Systematic Review of the Literature.

Autor:	Veronese N; Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy., Demurtas J; Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy.; Primary Care Department, USL Toscana Sud Est-Grosseto, Grosseto, Italy., Yang L; Department of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health Services, Calgary, AB, Canada.; Departments of Oncology and Community Health Sciences, University of Calgary, Calgary, AB, Canada., Tonelli R; Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy.; Respiratory Intensive Care Unit, University Hospital of Modena, Modena, Italy., Barbagallo M; Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy., Lopalco P; Department Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy., Lagolio E; Emergency Medicine (A&E) - Asl2 - H Santa Corona, Pietra Ligure and First Aid, H Santa Maria Misericordia, Albenga, Italy., Celotto S; Primary Care Department, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy., Pizzol D; Italian Agency for Development Cooperation, Khartoum, Sudan., Zou L; Exercise and Mental Health Laboratory, Shenzhen University, Shenzhen, China., Tully MA; School of Health Sciences, Institute of Mental Health Sciences, Ulster University, Newtownabbey, United Kingdom., Ilie PC; Research and Innovation Department, The Queen Elizabeth Hospital Foundation Trust, King's Lynn, United Kingdom., Trott M; The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, United Kingdom., López-Sánchez GF; Faculty of Sport Sciences, University of Murcia, Murcia, Spain., Smith L; The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, United Kingdom.
Jazyk:	angličtina
Zdroj:	Frontiers in medicine [Front Med (Lausanne)] 2020 Apr 24; Vol. 7, pp. 170. Date of Electronic Publication: 2020 Apr 24 (Print Publication: 2020).
DOI:	10.3389/fmed.2020.00170
Abstrakt:	The aim was to investigate the effectiveness of glucocorticoid therapy in patients with COVID-19. A systematic search of the literature across nine databases was conducted from inception until 15th March 2020, following the PRISMA guidelines. Patients with a validated diagnosis of COVID-19 and using corticosteroids were included, considering all health outcomes. Four studies with 542 Chinese participants were included. Two studies reported negative findings regarding the use of corticosteroids in patients with COVID-19, i.e., corticosteroids had a detrimental impact on clinical outcomes. One study reported no significant association between the use of corticosteroids and clinical outcomes. However, one study, on 201 participants with different stages of pneumonia due to COVID-19, found that in more severe forms, the administration of methylprednisolone significantly reduced the risk of death by 62%. The literature to date does not fully support the routine use of corticosteroids in COVID-19, but some findings suggest that methylprednisolone could lower mortality rate in more severe forms of the condition. (Copyright © 2020 Veronese, Demurtas, Yang, Tonelli, Barbagallo, Lopalco, Lagolio, Celotto, Pizzol, Zou, Tully, Ilie, Trott, López-Sánchez and Smith.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu