Weak association of a TNFRSF1A polymorphism with Behcet's disease in Chinese Han.

Autor: Hu L; The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's Republic of China. Electronic address: lilyhbwh@163.com., Tan H; The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's Republic of China. Electronic address: tanhandanthd@foxmail.com., Cao Q; The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's Republic of China. Electronic address: 314177565@qq.com., Yuan G; The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's Republic of China. Electronic address: gangxiangyuan@usa.com., Huang C; The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's Republic of China. Electronic address: 1058248980@qq.com., Su G; The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's Republic of China. Electronic address: bretty35@126.com., Kijlstra A; University Eye Clinic Maastricht, Maastricht, the Netherlands. Electronic address: aizekijlstra@gmail.com., Yang P; The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's Republic of China. Electronic address: peizengycmu@126.com.
Jazyk: angličtina
Zdroj: Experimental eye research [Exp Eye Res] 2020 Jul; Vol. 196, pp. 108045. Date of Electronic Publication: 2020 May 08.
DOI: 10.1016/j.exer.2020.108045
Abstrakt: The purpose of this study was to investigate whether single nucleotide polymorphisms (SNPs) of the tumor necrosis factor receptor superfamily (TNFRSF) and their ligand (TNFSF) gene are associated with susceptibility to Behcet's Disease (BD) in Chinese Han. A two-phase case-control study was performed in 1055 BD patients and 1829 healthy controls. A total of 27 SNPs was tested using MassARRAY iPLEX® technology. Data were analyzed using a Chi-square (χ2) test and Fisher's exact calibration test. The Bonferroni correction was applied for multiple testing. A statistically significant higher frequency of the A allele and a lower frequency of the G allele of rs1800692 was found in BD (Pc = 0.013, OR = 1.233, 95% CI = 1.103-1.379: Pc = 0.013, OR = 0.811, 95% CI = 0.725-0.907, respectively). Our findings indicate that TNFRSF1A might confer genetic susceptibility to BD in a Chinese Han population.
Competing Interests: Declaration of competing interest All authors have declared no conflicts of interest.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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