Prevalence of constipation in cystic fibrosis patients: a systematic review of observational studies.

Autor:	Stefano MA; Universidade Estadual de Campinas, Centro de Referência em Fibrose Cística, Campinas, SP, Brazil., Poderoso RE; Universidade Estadual de Campinas, Biblioteca da Faculdade de Ciências Médicas, Campinas, SP, Brazil., Mainz JG; University Klinikum Westbrandenburg Klinik für Kinder- und Jugendmedizin, Brandenburg Medical School (MHB), Head of Pediatric Pulmonology and Cystic Fibrosis, Hochstraße, Germany., Ribeiro JD; Universidade Estadual de Campinas, Departamento de Pediatria, Campinas, SP, Brazil; Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Centro de Referência em Fibrose Cística, Campinas, SP, Brazil., Ribeiro AF; Universidade Estadual de Campinas, Departamento de Pediatria, Campinas, SP, Brazil; Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Centro de Referência em Fibrose Cística, Campinas, SP, Brazil., Lomazi EA; Universidade Estadual de Campinas, Departamento de Pediatria, Campinas, SP, Brazil; Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Centro de Referência em Fibrose Cística, Campinas, SP, Brazil. Electronic address: elizete.apl@gmail.com.
Jazyk:	angličtina
Zdroj:	Jornal de pediatria [J Pediatr (Rio J)] 2020 Nov - Dec; Vol. 96 (6), pp. 686-692. Date of Electronic Publication: 2020 May 08.
DOI:	10.1016/j.jped.2020.03.004
Abstrakt:	Objective: To systematically revise the literature in search of data about the prevalence of constipation in patients with cystic fibrosis according to the publications in this field, which partly refer to guidelines defined in 2010 by the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. Sources: Systematic review selecting articles based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, including Cystic Fibrosis patients of all ages. Sources of information were selected to identify the articles without period limitation: CADTH - Canadian Agency for Drugs and Technologies in Health, CINAHL Complete, Clinical Trials US NIH, Cochrane Library, Embase, MEDLINE via Ovid, Scopus, Web Of Science, PubMed, SciELO, MEDLINE and LILACS , Health Systems Evidence, PDQ Evidence, CRD Canadian Agency for Drugs and Technologies in Health, INAHTA - International Network of Agencies for Health Technology Assessment, and PEDro. Findings: The prevalence of constipation was reported in eight observational studies. Only two studies assessed the frequency of constipation as a primary objective; in the others, constipation was quoted along with the prevalence of the spectrum of gastrointestinal manifestations. Altogether, the publications included 2,018 patients, the reported prevalence varied from 10% to 57%. Only two of the six articles published after 2010 followed the definition recommended by the European Society. Conclusions: Constipation is a frequent but still insufficiently assessed complaint of Cystic Fibrosis patients. The use of diverse diagnostic criteria restricts comparison and epidemiological conclusions, future studies should compulsorily apply the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition definition. (Copyright © 2020 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.)
Databáze:	MEDLINE
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