Can environmental pollutant bisphenol A increase metabolic risk in polycystic ovary syndrome?

Autor: Milanović M; University of Novi Sad, Faculty of Medicine, Department of Pharmacy, Novi Sad, Serbia., Milošević N; University of Novi Sad, Faculty of Medicine, Department of Pharmacy, Novi Sad, Serbia. Electronic address: natasa.milosevic@mf.uns.ac.rs., Sudji J; University of Novi Sad, Faculty of Medicine, Department of Pharmacy, Novi Sad, Serbia., Stojanoski S; University of Novi Sad, Faculty of Medicine, Oncology Institute of Vojvodina, Center for Imaging Diagnostics, Sremska Kamenica, Serbia., Atanacković Krstonošić M; University of Novi Sad, Faculty of Medicine, Department of Pharmacy, Novi Sad, Serbia., Bjelica A; University of Novi Sad, Faculty of Medicine, Department of Gynecology and Obstetrics, Clinics for Gynecology and Obstetrics, Clinical Center of Vojvodina, Novi Sad, Serbia., Milić N; University of Novi Sad, Faculty of Medicine, Department of Pharmacy, Novi Sad, Serbia., Medić Stojanoska M; University of Novi Sad, Faculty of Medicine, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Vojvodina, Novi Sad, Serbia.
Jazyk: angličtina
Zdroj: Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2020 Aug; Vol. 507, pp. 257-263. Date of Electronic Publication: 2020 May 06.
DOI: 10.1016/j.cca.2020.05.009
Abstrakt: Background: Bisphenol A (BPA), a widespread industrial substance is recognized as endocrine disrupting chemical and therefore could be associated with polycystic ovary syndrome (PCOS) related metabolic disturbances.
Patients: In this study 29 women of reproductive age with diagnosed PCOS were enrolled.
Methods: BPA in urine samples was analyzed by gas chromatography-mass spectrometry.
Results: BPA was detected in urines of 48.28% participants. The waist-to-height ratio (WtHR) was statistically significant higher in PCOS BPA+ in comparison to PCOS BPA- women (p = 0.046). PCOS BPA+ women had 6.88 times (95%Cl 1.3481-35.0600, z = 2.319, p = 0.020) higher risk for waist circumference above 80 cm and 4.95 odds (95%Cl 1.0169-24.096, z = 1.981, p = 0.048) to have WtHR over 0.5 when compared to PCOS BPA-. Statistically significant positive association between BPA urine concentrations and insulin serum levels (p = 0.038) was obtained. BPA urine values were associated with elevated HOMA-IR values and reduced HDL levels with moderate significance (p = 0.079 and p = 0.061, respectively). Also, there was 3.75 times (95%Cl 0.7936-17.7203, z = 1.668, p = 0.095) higher risk for PCOS BPA+ women to have testosterone levels above reference values.
Conclusion: The obtained results suggested that the BPA exposition in PCOS women was followed by increased metabolic risk through promotion of obesity, especially the visceral type, hyperinsulinemia, insulin resistance, dyslipidemia and elevated androgen levels.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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