| Autor: |
Sundarabharathi L; Department of Physics, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641020, Tamilnadu, India., Chinnaswamy M; Department of Physics, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641020, Tamilnadu, India., Ponnamma D; Center for Advanced Materials, Qatar University, P.O. Box 2713, Doha, Qatar., Parangusan H; Center for Advanced Materials, Qatar University, P.O. Box 2713, Doha, Qatar., Al-Maadeed MAA; Materials Science and Technology Program, Qatar University, P.O. Box 2713, Doha, Qatar. |
| Abstrakt: |
The present study aims to synthesize biocompatible and bioactive lanthanum (La 3+ )/strontium (Sr 2+ ) dual ion doped hydroxyapatite (HA) nanomaterials by sol-gel method. The discrete substitution of La 3+ and Sr 2+ in pure HA enhances the osteoconductivity. The co-substitution of various La 3+ concentrations (0.03, 0.06 and 0.1 M) regulates the physical and In Vitro properties. The study also investigates the effect of La 3+ /Sr 2+ substituents on the crystalline property, microstructure, photoluminescence and In Vitro bioactivity of HA samples. La 3+ /Sr 2+ co-substitution decreases the crystallite size of HA without any significant distortion of the crystal structure. In addition, the dual ions doping influences nanoparticles morphology by reducing the particle size from 75 to 20 nm. The In Vitro bioactivity tests for the La 3+ /Sr 2+ co-substituted HA confirm the osteoconductive boneapatite generating capacity. Bactericidal tests against Staphylococcus aureus and Pseudomonas aeruginosa stains show better resistivity of La 3+ /Sr 2+ -HA samples. To authenticate the biocompatibility and antimicrobial activity of the synthesized La 3+ /Sr 2+ dual doped HA nanoparticles for bone implant applications, different tests like cell viability and toxicity were conducted using human lung A549 cells. |
