In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier.

Autor: Alvebratt C; Department of Pharmacy, Uppsala Biomedical Centre P.O. Box 580, Uppsala University, SE-751 23, Uppsala, Sweden., Dening TJ; University of South Australia, UniSA: Clinical and Health Sciences, Adelaide SA 5000, Australia.; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of South Australia, Adelaide SA 5000, Australia., Åhlén M; Division of Nanotechnology and Functional Materials, Department of Engineering Sciences, Uppsala University, SE-75121 Uppsala, Sweden., Cheung O; Division of Nanotechnology and Functional Materials, Department of Engineering Sciences, Uppsala University, SE-75121 Uppsala, Sweden., Strømme M; Division of Nanotechnology and Functional Materials, Department of Engineering Sciences, Uppsala University, SE-75121 Uppsala, Sweden., Gogoll A; Department of Chemistry -Biomedical Centre P.O. Box 576, Uppsala University, Uppsala SE-751 23, Sweden., Prestidge CA; University of South Australia, UniSA: Clinical and Health Sciences, Adelaide SA 5000, Australia.; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of South Australia, Adelaide SA 5000, Australia., Bergström CAS; Department of Pharmacy, Uppsala Biomedical Centre P.O. Box 580, Uppsala University, SE-751 23, Uppsala, Sweden.; The Swedish Drug Delivery Center, Department of Pharmacy, Uppsala Biomedical Centre P.O. Box 580, Uppsala University, SE-751 23 Uppsala, Sweden.
Jazyk: angličtina
Zdroj: Pharmaceutics [Pharmaceutics] 2020 May 06; Vol. 12 (5). Date of Electronic Publication: 2020 May 06.
DOI: 10.3390/pharmaceutics12050426
Abstrakt: Lipid-based formulations can circumvent the low aqueous solubility of problematic drug compounds and increase their oral absorption. As these formulations are often physically unstable and costly to manufacture, solidification has been suggested as a way to minimize these issues. This study evaluated the physicochemical stability and in vitro performance of lipid-loaded mesoporous magnesium carbonate (MMC) particles with an average pore size of 20 nm. A medium chain lipid was loaded onto the MMC carrier via physical adsorption. A modified in vitro lipolysis setup was then used to study lipid release and digestion with 1 H nuclear magnetic resonance spectroscopy. The lipid loading efficiency with different solidification techniques was also evaluated. The MMC, unlike more commonly used porous silicate carriers, dissolved during the lipolysis assay, providing a rapid release of encapsulated lipids into solution. The digestion of the dispersed lipid-loaded MMC therefore resembled that of a coarse dispersion of the lipid. The stability data demonstrated minor degradation of the lipid within the pores of the MMC particles, but storage for three months did not reveal extensive degradation. To conclude, lipids can be adsorbed onto MMC, creating a solid powder from which the lipid is readily released into the solution during in vitro digestion. The chemical stability of the formulation does however merit further attention.
Competing Interests: Maria Strømme and Ocean Cheung declares that they are inventors of MMC with a large pore size (~20 nm). Maria Strømme declares that she is a partner Disruptive Materials, the company that now holds the patent for the MMC. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
Databáze: MEDLINE
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