| Autor: |
Chen H; Departments of Pathology., Molberg K; Departments of Pathology., Strickland AL; Departments of Pathology., Castrillon DH; Departments of Pathology.; Obstetrics and Gynecology.; Harold C. Simmons Comprehensive Cancer Center, UTSW Medical Center, Dallas, TX., Carrick K; Departments of Pathology., Jiang Q; Department of Pathology, Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China., Niu S; Departments of Pathology., Rivera-Colon G; Departments of Pathology., Gwin K; Departments of Pathology., Hinson S; Departments of Pathology., Lea J; Obstetrics and Gynecology.; Harold C. Simmons Comprehensive Cancer Center, UTSW Medical Center, Dallas, TX., Miller DS; Obstetrics and Gynecology.; Harold C. Simmons Comprehensive Cancer Center, UTSW Medical Center, Dallas, TX., Zheng W; Departments of Pathology.; Obstetrics and Gynecology.; Harold C. Simmons Comprehensive Cancer Center, UTSW Medical Center, Dallas, TX., Lucas E; Departments of Pathology.; Harold C. Simmons Comprehensive Cancer Center, UTSW Medical Center, Dallas, TX. |
| Jazyk: |
angličtina |
| Zdroj: |
The American journal of surgical pathology [Am J Surg Pathol] 2020 Aug; Vol. 44 (8), pp. 1050-1060. |
| DOI: |
10.1097/PAS.0000000000001503 |
| Abstrakt: |
The prevalence and significance of programmed death-1 ligand (PD-L1) expression in different types of tubo-ovarian carcinoma have not been well defined. We evaluated PD-L1 expression and CD8 tumor-infiltrating lymphocyte (TIL) density in whole tissue sections of 189 cases of tubo-ovarian carcinoma, including high-grade serous carcinoma (HGSC, n=100), clear cell carcinoma (CCC, n=24), endometrioid carcinoma (EmC, n=40), and mucinous carcinomas (MC, n=25). Using the tumor proportion score (TPS) with a 1% cutoff, PD-L1 expression was present in 21% of HGSC, 16.7% of CCC, 2.5% of EmC, and 4% of MC. Using the combined positive score (CPS) with a cutoff of 1, PD-L1 expression was present in 48% of HGSC, 25% of CCC, 20% of EmC, and 24% of MC. HGSC demonstrated significantly higher CD8 TIL density than CCC (P=0.013238), EmC (P=0.01341), or MC (P=0.004556). In HGSC, CD8 TIL density was directly correlated with PD-L1 positivity using either TPS (P=0.0008) or CPS (P=0.00011). Survival analysis of patients with high stage (stage III to IV) HGSC revealed PD-L1 positivity by TPS to be associated with improved progression-free survival (adjusted hazard ratio: 0.4912 vs. 2.036, P=0.0378). Although not statistically significant, a similar trend was observed in overall survival (adjusted hazard ratio: 0.3387 vs. 2.953, P=0.0548). In contrast, with CPS, no significant difference was identified between PD-L1-positive and negative groups in either progression-free survival (P=0.5086) or overall survival (P=0.7823). Neoadjuvant chemotherapy was associated with higher PD-L1 expression by TPS (P=0.00407) but not CPS. No significant difference in PD-L1 expression was detected in tumors from patients with germline BRCA1/2 mutations compared with germline mutation-negative tumors by either TPS or CPS. In conclusion, the prevalence of PD-L1 expression is variable in different types of tubo-ovarian carcinoma and is highest in HGSC. In high-stage HGSC, PD-L1 positivity in tumor cells is associated with an increased immune response and improved survival. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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