Ancient Hybridization with an Unknown Population Facilitated High-Altitude Adaptation of Canids.

Autor:	Wang MS; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China.; Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, CA.; Department of Ecology and Evolutionary Biology, University of California Santa Cruz, Santa Cruz, CA., Wang S; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China., Li Y; State Key Laboratory for Conservation and Utilization of Bio-Resource, Yunnan University, Kunming, China., Jhala Y; Wildlife Institute of India, Chandrabani, Dehradun, Uttarakhand, India., Thakur M; Zoological Survey of India, New Alipore, Kolkata, West Bengal, India., Otecko NO; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China., Si JF; Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture of China, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, China., Chen HM; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China., Shapiro B; Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, CA.; Department of Ecology and Evolutionary Biology, University of California Santa Cruz, Santa Cruz, CA., Nielsen R; Departments of Integrative Biology and Statistics, University of California Berkeley, Berkeley, CA.; Globe Institute, University of Copenhagen, Copenhagen, Denmark., Zhang YP; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.; State Key Laboratory for Conservation and Utilization of Bio-Resource, Yunnan University, Kunming, China.; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, China., Wu DD; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, China.
Jazyk:	angličtina
Zdroj:	Molecular biology and evolution [Mol Biol Evol] 2020 Sep 01; Vol. 37 (9), pp. 2616-2629.
DOI:	10.1093/molbev/msaa113
Abstrakt:	Genetic introgression not only provides material for adaptive evolution but also confounds our understanding of evolutionary history. This is particularly true for canids, a species complex in which genome sequencing and analysis has revealed a complex history of admixture and introgression. Here, we sequence 19 new whole genomes from high-altitude Tibetan and Himalayan wolves and dogs and combine these into a larger data set of 166 whole canid genomes. Using these data, we explore the evolutionary history and adaptation of these and other canid lineages. We find that Tibetan and Himalayan wolves are closely related to each other, and that ∼39% of their nuclear genome is derived from an as-yet-unrecognized wolf-like lineage that is deeply diverged from living Holarctic wolves and dogs. The EPAS1 haplotype, which is present at high frequencies in Tibetan dog breeds and wolves and confers an adaptive advantage to animals living at high altitudes, was probably derived from this ancient lineage. Our study underscores the complexity of canid evolution and demonstrates how admixture and introgression can shape the evolutionary trajectories of species. (© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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