Association of characteristics of tampon use with menstrual toxic shock syndrome in France.

Autor:	Billon A; Centre National de Référence de Staphylocoques - Institut des Agents Infectieux, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France., Gustin MP; Equipe Epidémiologie et Santé Internationale, Centre International de Recherche en Infectiologie, INSERM U1111, CNRS, UMR 5308, ENS de Lyon, Université Claude Bernard Lyon 1, Lyon, France., Tristan A; Centre National de Référence de Staphylocoques - Institut des Agents Infectieux, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.; Equipe Pathogénie des Staphylocoques, Centre International de Recherche en Infectiologie, INSERM U1111, CNRS, UMR 5308, ENS de Lyon, Université Claude Bernard Lyon 1, Lyon, France., Bénet T; Service d'Hygiène, Épidémiologie, Infectiovigilance et Prévention, Groupement Hospitalier Edouard Herriot, Hospices Civils de Lyon, Lyon, France., Berthiller J; Unité d'Appui Méthodologique - EPICIME - Cellule Innovation DRCi, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France., Gustave CA; Centre National de Référence de Staphylocoques - Institut des Agents Infectieux, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.; Equipe Pathogénie des Staphylocoques, Centre International de Recherche en Infectiologie, INSERM U1111, CNRS, UMR 5308, ENS de Lyon, Université Claude Bernard Lyon 1, Lyon, France., Vanhems P; Equipe Epidémiologie et Santé Internationale, Centre International de Recherche en Infectiologie, INSERM U1111, CNRS, UMR 5308, ENS de Lyon, Université Claude Bernard Lyon 1, Lyon, France.; Service d'Hygiène, Épidémiologie, Infectiovigilance et Prévention, Groupement Hospitalier Edouard Herriot, Hospices Civils de Lyon, Lyon, France.; Unité d'Appui Méthodologique - EPICIME - Cellule Innovation DRCi, Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France., Lina G; Centre National de Référence de Staphylocoques - Institut des Agents Infectieux, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.; Equipe Pathogénie des Staphylocoques, Centre International de Recherche en Infectiologie, INSERM U1111, CNRS, UMR 5308, ENS de Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Jazyk:	angličtina
Zdroj:	EClinicalMedicine [EClinicalMedicine] 2020 Mar 10; Vol. 21, pp. 100308. Date of Electronic Publication: 2020 Mar 10 (Print Publication: 2020).
DOI:	10.1016/j.eclinm.2020.100308
Abstrakt:	Background: Menstrual tampons are widely used in western countries. Indirect evidence suggests that tampon misuse could be associated with an increased risk of menstrual toxic shock syndrome (MTSS). The aim of this study was to determine what characteristics of tampon use are associated with increased risk of menstrual toxic shock syndrome (MTSS). Methods: A nationwide, case-control study in France, was conducted with women that use tampons with MTSS diagnoses according to the CDC diagnostic criteria ( n  = 55, from January 2011, to December 2017) and a control group of women with no MTSS history ( n  = 126, from February to December 2017). Information regarding tampon use during a 6-month period was collected. Associations between tampon use and MTSS were assessed using logistic regression models stratified by residential area. Findings: Compared to controls, women diagnosed with MTSS more frequently reported maximum tampon wear of >6 h (62% vs. 41%; P  = 0.02), overnight tampon use (77% vs. 54%; P =  0.006), and neither read nor followed tampon instructions in case of reading (65% vs. 42%; P =  0.006). In univariate analysis, MTSS risk was two-fold higher with tampon use for >6 consecutive hours (odds ratio, 2.3 [95% CI, 1.2-4.5]), and three-fold higher with tampon use during sleep for >8 h (odds ratio, 3.2 [95% CI, 1.4-7.7]). In multivariate logistic regression analysis, only maximum tampon use for >6 h (odds ratio, 2.03 [95% CI, 1.04-3.98]), and neither read nor followed the tampon instructions in case of reading (odds ratio, 2.25 [95% CI, 1.15-4.39]) were independently associated with MTSS. Interpretation: Our study suggests that the risk of MTSS was associated with using tampons for more than 6 h, overnight tampon use during sleep, and neither read nor followed tampon insertion instructions in case of reading. Funding: LABEX ECOFECT (ANR-11-LABX-0048) of Université de Lyon within the programme "Investissements d'Avenir" (ANR-11-IDEX-0007) operated by the French National Research Agency (ANR). Competing Interests: Thomas Benet was employed by bioMérieux from January 2018 to October 2019, working in a topic outside of the submitted work. Claude-Alexandre Gustave reports grants from LABEX ECOFECT (ANR-11-LABX-0048) of Université de Lyon within the programme “Investissements d'Avenir” (ANR-11-IDEX-0007) operated by the French National Research Agency (ANR) during the conduct of the study. Philippe Vanhems reports grants and personal fees outsides the submitted work from Astellas, Biosciences, MSD and Pfizer. (© 2020 Published by Elsevier Ltd.)
Databáze:	MEDLINE
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