An Unusual Case of Morphea in the Setting of Aplastic Anemia.
| Autor: | Mastrantonio S; Department of Dermatology, University of Nevada Las Vegas School of Medicine, Las Vegas, USA., Hinds BR; Department of Dermatology, University of California San Diego, San Diego, USA., Schneider JA; Department of Dermatology, University of California San Diego, San Diego, USA., Sennett R; Department of Dermatology, University of California San Diego, San Diego, USA., Cotter DG; Department of Dermatology, University of Nevada Las Vegas School of Medicine, Las Vegas, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2020 Apr 06; Vol. 12 (4), pp. e7562. Date of Electronic Publication: 2020 Apr 06. |
| DOI: | 10.7759/cureus.7562 |
| Abstrakt: | Cutaneous sclerosis occurs in association with a variety of systemic diseases, including hematologic malignancy, plasma cell dyscrasias, solid organ tumors, and other systemic autoimmune conditions. Herein, we present a unique case of morphea/lichen sclerosus overlap arising in association with aplastic anemia. To expand upon this rare case, we also review the literature surrounding paraneoplastic sclerosing skin disorders. A 53-year-old man presented with a 13-month history of progressive and generalized skin changes. Exam revealed irregular, hypopigmented indurated plaques with focal areas of scale on the bilateral axillae and hips, as well as hyperpigmented brown papules and plaques on the back. Laboratory evaluation revealed pancytopenia and positive anti-nuclear antibody (1:160). Bone marrow biopsy demonstrated hypocellular marrow consistent with aplastic anemia. Furthermore, skin biopsies revealed lichen sclerosus overlying superficial morphea, consistent with a paraneoplastic sclerodermoid-like eruption. While preparations for hematologic-directed therapies were made, skin-directed therapy with a combination topical steroids and topical calcineurin inhibitors was initiated. Eosinophilic fasciitis and scleroderma have been linked to aplastic anemia, and herein, we expand upon this phenomenon by presenting our case of generalized plaque morphea/lichen sclerosus overlap arising in the setting of aplastic anemia. Dermatologists must be aware of this rare association in order to identify precocious hematologic disease. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2020, Mastrantonio et al.) |
| Databáze: | MEDLINE |
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