Manganese-induced Parkinsonism in mice is reduced using a novel contaminated water sediment exposure model.

Autor: Freeman DM; Department of Environmental Health & Engineering, Johns Hopkins University, Baltimore, MD, USA., O'Neal R; Department of Environmental Health & Engineering, Johns Hopkins University, Baltimore, MD, USA., Zhang Q; Department of Environmental Health & Engineering, Johns Hopkins University, Baltimore, MD, USA., Bouwer EJ; Department of Environmental Health & Engineering, Johns Hopkins University, Baltimore, MD, USA., Wang Z; Department of Environmental Health & Engineering, Johns Hopkins University, Baltimore, MD, USA. Electronic address: zwang47@jhu.edu.
Jazyk: angličtina
Zdroj: Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2020 Aug; Vol. 78, pp. 103399. Date of Electronic Publication: 2020 Apr 22.
DOI: 10.1016/j.etap.2020.103399
Abstrakt: Heavy metals enter the aquatic environment and accumulate within water sediments, but these metal-sediment interactions remain to be explored within toxicity studies. We developed an exposure model in mice that encapsulates the aquatic microenvironment of metals before exposure. Male and female C57/BL6 mice were exposed via their drinking water to manganese contaminated sediment (Sed_Mn) or to manganese without sediment interaction (Mn) for six weeks. Sediment interaction did not alter weekly manganese ingestion from water in males or females. We analyzed motor impairment, a common feature in manganese-induced Parkinsonism, using the beam traversal, cylinder, and accelerating rotarod tests. Sed_Mn mice performed better overall compared to Mn mice and males were more sensitive to manganese than females in both Sed_Mn and Mn treatment groups. Our study indicates that metal-sediment interactions may alter metal toxicity in mammals and introduces a new exposure model to test the toxicity of metal contaminants of drinking water.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020. Published by Elsevier B.V.)
Databáze: MEDLINE
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