Solving the preoperative breast MRI conundrum: design and protocol of the MIPA study.

Autor: Sardanelli F; Department of Biomedical Sciences for Health, Università degli Studi di Milano, Via Morandi 30, 20097, San Donato Milanese, Italy. francesco.sardanelli@unimi.it.; Unit of Radiology, IRCCS Policlinico San Donato, Via Morandi 30, 20097, San Donato Milanese, Italy. francesco.sardanelli@unimi.it., Trimboli RM; Department of Biomedical Sciences for Health, Università degli Studi di Milano, Via Morandi 30, 20097, San Donato Milanese, Italy., Houssami N; Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia., Gilbert FJ; Department of Radiology, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK., Helbich TH; Department of Biomedical Imaging and Image-guided Therapy, Division of Molecular and Gender Imaging, Medical University of Vienna, Vienna, Austria., Alvarez Benito M; Department of Radiology, Hospital Universitario Reina Sofía, Córdoba, Spain., Balleyguier C; Department of Radiology, Gustave-Roussy Institute, Villejuif, France., Bazzocchi M; Institute of Radiology, Department of Medicine, University of Udine, University Hospital S. Maria della Misericordia, Udine, Italy., Bult P; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Calabrese M; Unit of Breast Radiology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Camps Herrero J; Department of Radiology, University Hospital of La Ribera, Alzira, Spain.; Jefa Corporativa del Área de la Mama, Ribera Salud Grupo, Valencia, Spain., Cartia F; Unit of Breast Imaging, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Cassano E; Breast Imaging Division, European Institute of Oncology, Milan, Italy., Clauser P; Department of Biomedical Imaging and Image-guided Therapy, Division of Molecular and Gender Imaging, Medical University of Vienna, Vienna, Austria., de Andrade DA; Department of Breast Surgery, Hospital Sírio Libanês, Sao Paulo, Brazil., de Lima Docema MF; Department of Radiology, Hospital Sírio Libanês, Sao Paulo, Brazil., Depretto C; Unit of Breast Imaging, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Forrai G; Department of Radiology, MHEK Teaching Hospital University Semmelweis, Budapest, Hungary.; Department of Radiology, Duna Medical Center, Budapest, Hungary., Girometti R; Institute of Radiology, Department of Medicine, University of Udine, University Hospital S. Maria della Misericordia, Udine, Italy., Harms SE; Breast Center of Northwest Arkansas, Fayetteville, AR, USA., Hilborne S; Department of Radiology, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK., Ienzi R; Department of Radiology Di.Bi.MED, University of Palermo, Policlinico P. Giaccone, Palermo, Italy., Lobbes MBI; Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.; Department of Radiology, Zuyderland Medical Center, Sittard-Geleen, The Netherlands., Losio C; Department of Breast Radiology, IRCCS Ospedale San Raffaele, Milan, Italy., Mann RM; Department of Radiology and Nuclear Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.; Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Montemezzi S; Department of Radiology, University Hospital of Verona, Verona, Italy., Obdeijn IM; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., Ozcan UA; Unit of Radiology, Acibadem Mehmet Ali Aydinlar University School of Medicine, Istanbul, Turkey., Pediconi F; Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy., Preibsch H; Department of Diagnostic and Interventional Radiology, University Hospital of Tübingen, Tübingen, Germany., Raya-Povedano JL; Deparment of Radiology, Hospital Universitario Reina Sofía, Córdoba, Spain., Sacchetto D; Kiwifarm Srl, La Morra, Italy.; Disaster Medicine Service 118, ASL CN1, Saluzzo, Italy.; CRIMEDIM, Research Center in Emergency and Disaster Medicine, Università del Piemonte Orientale, Novara, Italy., Scaperrotta GP; Unit of Breast Imaging, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Schlooz M; Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands., Szabo BK; Department of Radiology, Barking Havering and Redbridge University Hospitals NHS Trust, London, UK., Ulus OS; Unit of Radiology, Acibadem Mehmet Ali Aydinlar University School of Medicine, Istanbul, Turkey., Taylor DB; Medical School, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Australia.; Department of Radiology, Royal Perth Hospital, Perth, Australia., Van Goethem M; Gynecological Oncology Unit, Department of Obstetrics and Gynecology, Department of Radiology, Multidisciplinary Breast Clinic, Antwerp University Hospital-University of Antwerp, Antwerp, Belgium., Veltman J; Maatschap Radiologie Oost-Nederland, Oldenzaal, The Netherlands., Weigel S; Institute of Clinical Radiology and Reference Center for Mammography, University of Münster, Münster, Germany., Wenkel E; Department of Radiology, University Hospital of Erlangen, Erlangen, Germany., Zuiani C; Institute of Radiology, Department of Medicine, University of Udine, University Hospital S. Maria della Misericordia, Udine, Italy., Di Leo G; Unit of Radiology, IRCCS Policlinico San Donato, Via Morandi 30, 20097, San Donato Milanese, Italy.
Jazyk: angličtina
Zdroj: European radiology [Eur Radiol] 2020 Oct; Vol. 30 (10), pp. 5427-5436. Date of Electronic Publication: 2020 May 06.
DOI: 10.1007/s00330-020-06824-7
Abstrakt: Despite its high diagnostic performance, the use of breast MRI in the preoperative setting is controversial. It has the potential for personalized surgical management in breast cancer patients, but two of three randomized controlled trials did not show results in favor of its introduction for assessing the disease extent before surgery. Meta-analyses showed a higher mastectomy rate in women undergoing preoperative MRI compared to those who do not. Nevertheless, preoperative breast MRI is increasingly used and a survey from the American Society of Breast Surgeons showed that 41% of respondents ask for it in daily practice. In this context, a large-scale observational multicenter international prospective analysis (MIPA study) was proposed under the guidance of the European Network for the Assessment of Imaging in Medicine (EuroAIM). The aims were (1) to prospectively and systematically collect data on consecutive women with a newly diagnosed breast cancer, not candidates for neoadjuvant therapy, who are offered or not offered breast MRI before surgery according to local practice; (2) to compare these two groups in terms of surgical and clinical endpoints, adjusting for covariates. The underlying hypotheses are that MRI does not cause additional mastectomies compared to conventional imaging, while reducing the reoperation rate in all or in subgroups of patients. Ninety-six centers applied to a web-based call; 36 were initially selected based on volume and quality standards; 27 were active for enrollment. On November 2018, the target of 7000 enrolled patients was reached. The MIPA study is presently at the analytic phase. Key Points • Breast MRI has a high diagnostic performance but its utility in the preoperative setting is controversial. • A large-scale observational multicenter prospective study was launched to compare women receiving with those not receiving preoperative MRI. • Twenty-seven centers enrolled more than 7000 patients. The study is presently at the analytic phase.
Databáze: MEDLINE
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