Transcriptome of the parasitic flatworm Schistosoma mansoni during intra-mammalian development.

Autor: Wangwiwatsin A; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.; Department of Biology, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand., Protasio AV; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.; Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge, United Kingdom., Wilson S; Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge, United Kingdom., Owusu C; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Holroyd NE; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Sanders MJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Keane J; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Doenhoff MJ; School of Life Sciences, University of Nottingham, University Park, Nottingham, United Kingdom., Rinaldi G; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Berriman M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 May 06; Vol. 14 (5), pp. e0007743. Date of Electronic Publication: 2020 May 06 (Print Publication: 2020).
DOI: 10.1371/journal.pntd.0007743
Abstrakt: Schistosomes are parasitic blood flukes that survive for many years within the mammalian host vasculature. How the parasites establish a chronic infection in the hostile bloodstream environment, whilst evading the host immune response is poorly understood. The parasite develops morphologically and grows as it migrates to its preferred vascular niche, avoiding or repairing damage from the host immune system. In this study, we investigated temporal changes in gene expression during the intra-mammalian development of Schistosoma mansoni. RNA-seq data were analysed from parasites developing in the lung through to egg-laying mature adult worms, providing a comprehensive picture of in vivo intra-mammalian development. Remarkably, genes involved in signalling pathways, developmental control, and adaptation to oxidative stress were up-regulated in the lung stage. The data also suggested a potential role in immune evasion for a previously uncharacterised gene. This study not only provides a large and comprehensive data resource for the research community, but also reveals new directions for further characterising host-parasite interactions that could ultimately lead to new control strategies for this neglected tropical disease pathogen.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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