An intelligent vancomycin release system for preventing surgical site infections of bone tissues.

Autor: Li Y; College of Medicine, Southwest Jiaotong University, No. 111 Beiyiduan, Second Ring Road, Chengdu 610036, Sichuan Province, China and CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing 100000, China. wanglei@nanoctr.cn wanghao@nanoctr.cn and Department of Orthopaedics, The 8thMedical Center of Chinese PLA General Hospital, Jia No.17 Heishanhu road, Beijing 100000, China. cuixuprossor@163.com., Li G; College of Medicine, Hebei North University, No.11 Diamond South Road, High-tech Zone, Zhangjiakou 075000, Hebei Province, China., Sha X; College of Medicine, Southwest Jiaotong University, No. 111 Beiyiduan, Second Ring Road, Chengdu 610036, Sichuan Province, China and CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing 100000, China. wanglei@nanoctr.cn wanghao@nanoctr.cn and Department of Orthopaedics, The 8thMedical Center of Chinese PLA General Hospital, Jia No.17 Heishanhu road, Beijing 100000, China. cuixuprossor@163.com., Li L; Department of Orthopaedics, The 8thMedical Center of Chinese PLA General Hospital, Jia No.17 Heishanhu road, Beijing 100000, China. cuixuprossor@163.com., Zhang K; CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing 100000, China. wanglei@nanoctr.cn wanghao@nanoctr.cn., Liu D; Department of Orthopaedics, The 8thMedical Center of Chinese PLA General Hospital, Jia No.17 Heishanhu road, Beijing 100000, China. cuixuprossor@163.com., Hao Y; Department of Orthopaedics, The 8thMedical Center of Chinese PLA General Hospital, Jia No.17 Heishanhu road, Beijing 100000, China. cuixuprossor@163.com., Cui X; Department of Orthopaedics, The 8thMedical Center of Chinese PLA General Hospital, Jia No.17 Heishanhu road, Beijing 100000, China. cuixuprossor@163.com., Wang L; CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing 100000, China. wanglei@nanoctr.cn wanghao@nanoctr.cn., Wang H; CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing 100000, China. wanglei@nanoctr.cn wanghao@nanoctr.cn.
Jazyk: angličtina
Zdroj: Biomaterials science [Biomater Sci] 2020 Jun 02; Vol. 8 (11), pp. 3202-3211.
DOI: 10.1039/d0bm00255k
Abstrakt: Preventing surgical site infections (SSIs) of implants has drawn significant attention in both basic and clinical research. Implants with convenient preparation methods and intelligent drug release capabilities are highly needed to resist bacterial infection. Herein, we designed an intelligent drug-release system, which can be instantly incorporated with implants during the surgical process. The drug-release system involves β-glycerophosphate (β-GP) and chitosan (CS) as a thermosensitive hydrogel for instant construction onto implants and hyaluronic acid (HA) as a trigger to release vancomycin hydrochloride (VH) on demand. Tertiary calcium phosphate (TCP) scaffolds (implants) are vacuum-adsorbed in a solution of the intelligent vancomycin-release system (VH-HA-CS/β-GP), followed by heating for 40 min at 80 °C to form VH-HA-CS/β-GP@TCP. The drug-release hydrogel intelligently releases vancomycin depending on the concentration of hyaluronidase, which is secreted by Staphylococcus aureus (S. aureus) in infection sites. Furthermore, VH-HA-CS/β-GP@TCP showed effective antibacterial properties in vitro and in vivo. The VH-HA-CS/β-GP drug-release system can be conveniently prepared during surgery for intelligently preventing SSIs in bone tissue.
Databáze: MEDLINE