| Autor: |
Jaros SW; Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wrocław, Poland., Król J; Department of Veterinary Microbiology, Wrocław University of Environmental and Life Sciences, Norwida 31, 50-375 Wrocław, Poland., Bażanów B; Department of Veterinary Microbiology, Wrocław University of Environmental and Life Sciences, Norwida 31, 50-375 Wrocław, Poland., Poradowski D; Department of Animal Physiology and Biostructure, Wrocław University of Environmental and Life Sciences, Kożuchowska 1, 51-631 Wrocław, Poland., Chrószcz A; Department of Animal Physiology and Biostructure, Wrocław University of Environmental and Life Sciences, Kożuchowska 1, 51-631 Wrocław, Poland., Nesterov DS; Centro de Química Estrutural and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal.; Research Institute of Chemistry, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya st., 117198 Moscow, Russia., Kirillov AM; Centro de Química Estrutural and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal.; Research Institute of Chemistry, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya st., 117198 Moscow, Russia., Smoleński P; Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wrocław, Poland. |
| Abstrakt: |
The present study reports the synthesis, characterization, and crystal structure of a novel bioactive metal-organic framework, [Ag 4 ( µ -PTA) 2 (µ 3 -PTA) 2 ( µ 4 -pma)(H 2 O) 2 ] n ·6nH 2 O (bioMOF 1 ), which was assembled from silver(I) oxide, 1,3,5-triaza-7-phosphaadamantane (PTA), and pyromellitic acid (H 4 pma). This product was isolated as a stable microcrystalline solid and characterized by standard methods, including elemental analysis, 1 H and 31 P{ 1 H} NMR and FTIR spectroscopy, and single crystal X-ray diffraction. The crystal structure of 1 disclosed a very complex ribbon-pillared 3D metal-organic framework driven by three different types of bridging ligands ( µ -PTA, µ 3 -PTA, and µ 4 -pma 4- ). Various bioactivity characteristics of bioMOF 1 were investigated, revealing that this compound acts as a potent antimicrobial against pathogenic strains of standard Gram-negative ( Escherichia coli , Pseudomonas aeruginosa ) and Gram-positive ( Staphylococcus aureus ) bacteria, as well as a yeast ( Candida albicans ). Further, 1 showed significant antiviral activity against human adenovirus 36 (HAdV-36). Finally, bioMOF 1 revealed high cytotoxicity toward an abnormal epithelioid cervix carcinoma (HeLa) cell line with low toxicity toward a normal human dermal fibroblast (NHDF) cell line. This study not only broadens the family of PTA-based coordination polymers but also highlights their promising multifaceted bioactivity. |
