The Predictive Value of Proportional Evaluation Based on the Metabolic Activity of Cervical Lymph Nodes on PET/CT Imaging in Patients with Larynx Cancer.

Autor: Sağlampınar Karyağar S; University of Health Sciences Turkey, İstanbul Okmeydanı Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkey., Karyağar S; University of Health Sciences Turkey, İstanbul Okmeydanı Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkey., Güven O; University of Health Sciences Turkey, İstanbul Okmeydanı Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkey., Üstün O; University of Health Sciences Turkey, İstanbul Okmeydanı Training and Research Hospital, Clinic of Otorhinolaryngology, İstanbul, Turkey., Atar Y; University of Health Sciences Turkey, İstanbul Okmeydanı Training and Research Hospital, Clinic of Otorhinolaryngology, İstanbul, Turkey., Uyar Y; University of Health Sciences Turkey, İstanbul Okmeydanı Training and Research Hospital, Clinic of Otorhinolaryngology, İstanbul, Turkey.
Jazyk: angličtina
Zdroj: Molecular imaging and radionuclide therapy [Mol Imaging Radionucl Ther] 2020 Apr 29; Vol. 29 (2), pp. 59-64.
DOI: 10.4274/mirt.galenos.2019.92300
Abstrakt: Objectives: We aimed to evaluate the proportional values of maximum standardized uptake value (SUV max ) for cervical lymph nodes on 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for prediction of the presence of metastasis in patients with larynx squamous cell cancer (LSCC).
Methods: This retrospective study involved 43 patients with LSCC. All patients underwent resection of the primary tumor and neck dissection within 4 weeks after undergoing 18 F-FDG PET/CT examinations. Receiver operating characteristic (ROC) analysis was performed to evaluate the lymph node SUV max /primary tumor SUV max (SUV max LN/SUV max PT), lymph node SUV max /aortic SUV max (SUV max LN/SUV max A), and lymph node SUV max / liver SUV max (SUV max LN/SUV max L) ratios for diagnosis of lymph node metastasis.
Results: SUV max LN/SUV max A, SUV max LN/SUV max L, and SUV max LN/SUV max PT rates were significantly higher in metastatic lymph nodes compared to non-metastatic nodes. ROC analysis for metastasis showed that the cut-off thresholds were 3.87 for SUV max LN; 1.78 for SUV max LN /SUV max A; 1.08 for SUV max LN/SUV max L; and 0.36 for SUV max LN/SUV max PT. The diagnostic sensitivity, specificity and AUC were 83.7%, 77%, 0.856 for SUV max LN; 79.7%, 84%, 1.78 for SUV max LN/SUV max A; 84.1%, 76%, 0.833 for SUV max LN/SUV max L; and 53.6%, 76%, 0.666 for SUV max LN/SUV max PT, respectively.
Conclusion: SUV max LN/SUV max A, SUV max LN/SUV max L, and SUV max LN/SUV max PT ratios can be safely used for diagnosis of cervical lymph node metastasis in patients with LSCC.
Databáze: MEDLINE
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