A microsporidian impairs Plasmodium falciparum transmission in Anopheles arabiensis mosquitoes.

Autor:	Herren JK; International Centre of Insect Physiology and Ecology (ICIPE), Kasarani, Nairobi, Kenya. jherren@icipe.org.; MRC-University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow, G61 1QH, UK. jherren@icipe.org., Mbaisi L; International Centre of Insect Physiology and Ecology (ICIPE), Kasarani, Nairobi, Kenya.; Centre for Biotechnology and Bioinformatics (CEBIB), University of Nairobi, Nairobi, Kenya., Mararo E; International Centre of Insect Physiology and Ecology (ICIPE), Kasarani, Nairobi, Kenya., Makhulu EE; International Centre of Insect Physiology and Ecology (ICIPE), Kasarani, Nairobi, Kenya., Mobegi VA; Centre for Biotechnology and Bioinformatics (CEBIB), University of Nairobi, Nairobi, Kenya.; Department of Biochemistry, University of Nairobi, Nairobi, Kenya., Butungi H; International Centre of Insect Physiology and Ecology (ICIPE), Kasarani, Nairobi, Kenya.; University of the Witwaterstrand, Wits Research Institute for Malaria, Johannesburg, South Africa., Mancini MV; MRC-University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow, G61 1QH, UK., Oundo JW; International Centre of Insect Physiology and Ecology (ICIPE), Kasarani, Nairobi, Kenya., Teal ET; International Centre of Insect Physiology and Ecology (ICIPE), Kasarani, Nairobi, Kenya., Pinaud S; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK., Lawniczak MKN; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK., Jabara J; International Centre of Insect Physiology and Ecology (ICIPE), Kasarani, Nairobi, Kenya., Nattoh G; International Centre of Insect Physiology and Ecology (ICIPE), Kasarani, Nairobi, Kenya.; Pan African University Institute for Basic Sciences Technology & Innovation, Nairobi, Kenya., Sinkins SP; MRC-University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow, G61 1QH, UK.
Jazyk:	angličtina
Zdroj:	Nature communications [Nat Commun] 2020 May 04; Vol. 11 (1), pp. 2187. Date of Electronic Publication: 2020 May 04.
DOI:	10.1038/s41467-020-16121-y
Abstrakt:	A possible malaria control approach involves the dissemination in mosquitoes of inherited symbiotic microbes to block Plasmodium transmission. However, in the Anopheles gambiae complex, the primary African vectors of malaria, there are limited reports of inherited symbionts that impair transmission. We show that a vertically transmitted microsporidian symbiont (Microsporidia MB) in the An. gambiae complex can impair Plasmodium transmission. Microsporidia MB is present at moderate prevalence in geographically dispersed populations of An. arabiensis in Kenya, localized to the mosquito midgut and ovaries, and is not associated with significant reductions in adult host fecundity or survival. Field-collected Microsporidia MB infected An. arabiensis tested negative for P. falciparum gametocytes and, on experimental infection with P. falciparum, sporozoites aren't detected in Microsporidia MB infected mosquitoes. As a microbe that impairs Plasmodium transmission that is non-virulent and vertically transmitted, Microsporidia MB could be investigated as a strategy to limit malaria transmission.
Databáze:	MEDLINE
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