Meaningful improvement thresholds in measures of pain and quality of life in oral lichen planus.

Autor: Wiriyakijja P; UCL Eastman Dental Institute, London, UK.; Department of Oral Medicine, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand., Porter S; UCL Eastman Dental Institute, London, UK., Fedele S; UCL Eastman Dental Institute, London, UK.; NIHR University College London Hospitals Biomedical Research Centre, London, UK., Hodgson T; Eastman Dental Hospital, UCLH Foundation NHS Trust London, London, UK., McMillan R; Eastman Dental Hospital, UCLH Foundation NHS Trust London, London, UK., Shephard M; Eastman Dental Hospital, UCLH Foundation NHS Trust London, London, UK., Ni Riordain R; UCL Eastman Dental Institute, London, UK.; Department of Oral Medicine, Cork University Dental School and Hospital, Cork, Ireland.
Jazyk: angličtina
Zdroj: Oral diseases [Oral Dis] 2020 Oct; Vol. 26 (7), pp. 1464-1473. Date of Electronic Publication: 2020 May 26.
DOI: 10.1111/odi.13379
Abstrakt: Objectives: To evaluate the responsiveness of measures of pain and oral health-related quality of life (OH-QoL) in patients with oral lichen planus (OLP) and to determine thresholds for minimal important change (MIC) and minimal important difference (MID) for use in this patient population.
Methods: Data from baseline and 4-month follow-up including Visual Analog Scale (VAS), Numerical Rating Scale (NRS), 14-item Oral Health Impact Profile (OHIP-14), 15-item and 26-item Chronic Oral Mucosal Disease Questionnaire (COMDQ-15; COMDQ-26) were collected from 157 patients with OLP. Responsiveness was assessed by testing hypotheses and calculating the area under the curve. MIC and MID were established based on triangulation of distribution-based and anchor-based estimates.
Results: The results supported adequate responsiveness of VAS, NRS, COMDQ-15 and COMDQ-26 for use in OLP, while the OHIP-14 demonstrated relatively low sensitivity to detect improvement in the OLP status. Recommended meaningful improvement thresholds were as follows: VAS (MIC 16 mm; MID 18 mm), NRS (MIC/MID 2 points), OHIP-14 (MIC/MID 5 points), COMDQ-15 (MIC 5 points; MID 6 points) and COMDQ-26 (MIC/MID 9 points).
Conclusion: This study provides some evidence of responsiveness as well as establishing meaningful improvement thresholds in scores of pain and OH-QoL measures in OLP.
(© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.)
Databáze: MEDLINE
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