| Autor: |
Simonsen JA; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark., Thilsing-Hansen K; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark., Høilund-Carlsen PF; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Gerke O; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Andersen TL; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark. |
| Abstrakt: |
The issue of whether 99m Tc-DTPA can replace 51 Cr-EDTA for measurement of plasma clearance as a surrogate for glomerular filtration rate (GFR) is of great relevance to daily clinical practice. Prompted by the shortage of 51 Cr-EDTA we conducted a head-to-head comparison in patients attending our department for GFR determination. The two tracers (3.7 MBq of 51 Cr-EDTA and 8 MBq of 99m Tc-DTPA) were administered intravenously immediately after each other, and the standard number of blood samples were drawn. Fifty-four patients were enrolled. In 51 of these, single-sample measurement was performed with the following results: GFR EDTA was 84.6 ± 23.3 mL/min, GFR DTPA was 84.2 ± 24.7 mL/min. The mean difference was 0.4 ± 2.8 mL/min, p = 0.32, and results based on the two tracers were highly correlated ( r = 0.995). GFR DTPA exceeded GFR EDTA at high GFR values (difference < 0 at GFR EDTA >91.4 mL/min) and vice versa (difference > 0 at GFR EDTA < 91.4 mL/min). However, differences fell within few GFR units that most often will have no clinical consequence. We therefore conclude that 99m Tc-DTPA can replace 51 Cr-EDTA for single-sample determination of GFR in a clinical setting. |
