[Determination of cytokines and adhesion molecules in elderly and senile patients with aortic valve calcification.]

Autor: Mikheeva NA; Saint-Petersburg Institute of Bioregulation and Gerontology, 3 Dinamo pr., St. Petersburg, 197110, Russian Federation., Gulyaev NI; S.M.Kirov Military Medical Academy, 6 Acad. Lebedeva str., St. Petersburg 194044, Russian Federation, e-mail: ig_oleksjuk@mail.ru., Oleksyuk IB; S.M.Kirov Military Medical Academy, 6 Acad. Lebedeva str., St. Petersburg 194044, Russian Federation, e-mail: ig_oleksjuk@mail.ru., Kozlov KL; Saint-Petersburg Institute of Bioregulation and Gerontology, 3 Dinamo pr., St. Petersburg, 197110, Russian Federation.; S.M.Kirov Military Medical Academy, 6 Acad. Lebedeva str., St. Petersburg 194044, Russian Federation, e-mail: ig_oleksjuk@mail.ru., Solovyev MA; E.D.Gol'dberg Institute for Pharmacology and Regenerative Medicine, 3 pr. Lenina, Tomsk 634028, Russian Federation., Tcygan NV; S.M.Kirov Military Medical Academy, 6 Acad. Lebedeva str., St. Petersburg 194044, Russian Federation, e-mail: ig_oleksjuk@mail.ru.; B.P.Konstantinov Petersburg Nuclear Physics Institute of National Research Centre «Kurchatov Institute», 1, mkr. Orlova Roscha, Gatchina, Leningrad region 188300, Russian Federation., Mikhailov SS; S.M.Kirov Military Medical Academy, 6 Acad. Lebedeva str., St. Petersburg 194044, Russian Federation, e-mail: ig_oleksjuk@mail.ru.
Jazyk: ruština
Zdroj: Advances in gerontology = Uspekhi gerontologii [Adv Gerontol] 2020; Vol. 33 (1), pp. 107-112.
Abstrakt: A laboratory study of the cytokine profile and the content of the intercellular adhesion molecules was performed in 38 patients with initial signs of aortic hemilunus calcification. It has been determined that the content of IL-6 and IL-8 had significantly higher values compared with the control group, which indicates the direct role of nonspecific chronic inflammation in the development of calcifying aortic valve damage. A significantly lower content of sE-selectin was also identified, which may indicate the absence of activation of adhesion molecules at the initial stage of aortic valve calcification. Further study of the dynamics of sE- and sP-selectins content in the process of development of acceleration of blood flow in the aortic valve and the formation of stenosis is needed.
Databáze: MEDLINE
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