FIP1L1-PDGFRA-Positive Hypereosinophilia Presenting with Bilateral Extracranial Carotid Artery Aneurysms.

Autor: Moalong KMC; Division of Adult Neurology, Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. Electronic address: kevin.moalong@gmail.com., Diestro JDB; Division of Diagnostic and Therapeutic Neuroradiology, Department of Medical Imaging, St. Michael's Hospital, University of Toronto, Toronto, Canada., Espiritu AI; Division of Adult Neurology, Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines; Department of Clinical Epidemiology, College of Medicine, University of the Philippines Manila, Manila, Philippines., Lucero JAC; Department of Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines; Division of Hematology, Department of Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines., de la Cruz APRL; Department of Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines., Valencia JM; Department of Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines; Division of Cardiology, Department of Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines., Chua EM 3rd; Division of Thoracic and Cardiovascular Surgery, Department of Surgery, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines., Cenina ARF; Division of Adult Neurology, Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines., Spears J; Division of Diagnostic and Therapeutic Neuroradiology, Department of Medical Imaging, St. Michael's Hospital, University of Toronto, Toronto, Canada; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Canada., San Jose MCZ; Division of Adult Neurology, Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Jazyk: angličtina
Zdroj: World neurosurgery [World Neurosurg] 2020 Jul; Vol. 139, pp. 419-422. Date of Electronic Publication: 2020 Apr 29.
DOI: 10.1016/j.wneu.2020.04.119
Abstrakt: Objective: To describe a case of an adult female Filipino with hypereosinophilia and bilateral carotid artery aneurysms who subsequently developed bilateral cerebral hemisphere strokes following aneurysm stenting.
Case Description: A 57-year-old female patient with persistent hypereosinophilia presented with progressively enlarging bilateral neck masses, revealed to be carotid artery aneurysms on computed tomography angiography. Following surgical exploration, she later developed right-sided hemiplegia, aphasia, and right hemianopia. Cranial computed tomography revealed infarcts on both middle cerebral artery territories. Bone marrow biopsy and fluorescent in situ hybridization revealed findings suggestive of hypereosinophilic syndrome. She was started on standard aspirin and statin therapy and was discharged sixteen days after the procedure. Partial improvement of neurologic deficits was noted two months later on follow up. Chemotherapy with imatinib was initiated.
Conclusions: This patient's prothrombotic state from FIP1L1-PDGFRA-positive hypereosinophilia may have led to large carotid artery aneurysm formation and intramural thrombosis. This case demonstrates a possible and heretofore undocumented neurovascular sequela of hypereosinophilic syndrome.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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