Subclinical BCG-osis in a Captive Badger (Meles meles) with Lymphoma.

Autor: Bianco C; Pathology Department, Animal and Plant Health Agency, Lasswade, UK. Electronic address: Carlo.Bianco@apha.gov.uk., Lesellier S; Animal and Plant Health Agency, Weybridge, UK., Barrat J; Nancy Laboratory for Rabies and Wildlife, Malzéville, France., Richomme C; Nancy Laboratory for Rabies and Wildlife, Malzéville, France., Boschiroli ML; University Paris-Est, French Agency for Food, Environmental and Occupational Health and Safety, Laboratory for Animal Health, Maisons-Alfort, France., Núñez A; Pathology Department, Animal and Plant Health Agency, Weybridge, UK.
Jazyk: angličtina
Zdroj: Journal of comparative pathology [J Comp Pathol] 2020 Apr; Vol. 176, pp. 76-80. Date of Electronic Publication: 2020 Mar 16.
DOI: 10.1016/j.jcpa.2020.02.009
Abstrakt: Subclinical systemic dissemination of Bacillus Calmette-Guérin (BCG) is described in a captive badger (Meles meles) with lymphoma. An adult female European badger was vaccinated per os with BCG and after 8 weeks post-mortem examination identified marked lymphadenomegaly and multinodular hepatic lesions. The histopathology and immunohistochemistry confirmed a multicentric T-cell lymphoma, associated with high BCG bacterial load in numerous tissues. The histology did not identify BCG-associated lesions. The scenario suggested that the T-cell lymphoma likely favoured the dissemination of the BCG ('BCG-osis'). Given that lymphoma is rare in badgers, this neoplasm should not interfere with the efficacy of large-scale vaccination programmes.
(Crown Copyright © 2020. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: