Ambulatory urodynamic monitoring assessment of dorsal genital nerve stimulation for suppression of involuntary detrusor contractions following spinal cord injury: a pilot study.

Autor: Doherty SP; Aspire Centre for Rehabilitation Engineering and Assistive Technology, University College London, London, UK. sean.doherty.15@ucl.ac.uk.; London Spinal Cord Injury Centre, Royal National Orthopaedic Hospital, London, UK. sean.doherty.15@ucl.ac.uk., Vanhoestenberghe A; Aspire Centre for Rehabilitation Engineering and Assistive Technology, University College London, London, UK., Duffell LD; Aspire Centre for Rehabilitation Engineering and Assistive Technology, University College London, London, UK., Hamid R; London Spinal Cord Injury Centre, Royal National Orthopaedic Hospital, London, UK., Knight SL; London Spinal Cord Injury Centre, Royal National Orthopaedic Hospital, London, UK.
Jazyk: angličtina
Zdroj: Spinal cord series and cases [Spinal Cord Ser Cases] 2020 Apr 30; Vol. 6 (1), pp. 30. Date of Electronic Publication: 2020 Apr 30.
DOI: 10.1038/s41394-020-0279-4
Abstrakt: Study Design: A prospective interventional pilot study using within-individual comparisons.
Objectives: To assess the effect of dorsal genital nerve stimulation (DGNS) on urine-storage parameters in participants with spinal cord injury (SCI) and neurogenic detrusor overactivity (NDO) during natural bladder filling.
Setting: The London Spinal Cord Injuries Centre at the Royal National Orthopaedic Hospital, Stanmore, UK.
Methods: Ambulatory urodynamic monitoring (AUM) was carried out with and without DGNS, before and after a week of using DGNS at home. DGNS was applied on-demand by four participants with bladder sensation, and both continuously and intermittently by one participant with absent sensation. A Wilcoxon sign-rank test was used to test paired results of changes within an AUM session.
Results: Urodynamic outcomes were improved using DGNS. Bladder capacity was increased from 244 ± 59 to 346 ± 61 ml (p = 0.0078), a mean change of 46 ± 25%. Maximum detrusor pressure was decreased from 58 ± 18 to 47 ± 18 cmH 2 O (p = 0.0156), a change of 17 ± 13%, and average peak detrusor pressure was decreased from 56 ± 16 to 31 ± 128 cmH 2 O (p = 0.0156), a mean reduction of 50 ± 19%. There was an increase in the number of detrusor contractions from the first involuntary detrusor contraction to a strong desire, urgency or incontinence, from 1.5 ± 1.4 to 4.3 ± 1.7, and an increase in time of 23 ± 22 min. There were no changes in baseline outcomes following home use of DGNS.
Conclusions: DGNS may be applied on-demand, intermittently or continuously, to increase bladder capacity, decrease storage pressures and provide extra time. Improvements were made in addition to existing antimuscarinic medication regimes.
Databáze: MEDLINE
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