Role of 18 F-Flurodeoxyglucose Positron-Emission Tomography/Computed Tomography in the Evaluation of Early Response to Neoadjuvant Chemotherapy in Patients with Locally Advanced Triple-Negative Breast Cancer.

Autor:	Basnet B; Department of Radiology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Goyal P; Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Mahawar V; Department of Radiology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Bothra SJ; Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Agrawal C; Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Thapa BB; Department of Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Talwar V; Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Jain P; Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Babu Koyyala VP; Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Goel V; Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Batra U; Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Doval DC; Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
Jazyk:	angličtina
Zdroj:	Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India [Indian J Nucl Med] 2020 Apr-Jun; Vol. 35 (2), pp. 105-109. Date of Electronic Publication: 2020 Mar 12.
DOI:	10.4103/ijnm.IJNM_210_19
Abstrakt:	Background: Response evaluation in locally advanced breast cancer is done through different methods ranging from clinical examination to magnetic resonance imaging, however evaluation with positron-emission tomography/computed tomography (PET/CT) in now being incorporated for the response evaluation. The aim of the present study is to correlate response to neoadjuvant chemotherapy (NACT) with PET/CT scan. Materials and Methods: The present study is a retrospective analysis of 30 locally advanced, triple-negative breast cancer patients. PET/CT scan was done pretreatment and post three and six cycles of NACT and was correlated with pathologic complete response (pCR). Responding disease was considered when there was at least a 50% reduction in the longest diameter. Results: The median pretreatment size of the breast lesion in CT scan was 3.9 ± 2.3 cm (2-12 cm) and maximum standardized uptake value (SUVmax) on PET/CT was 8.5 ± 5.5 (2.9-24). Among the responders, the median decrease in size of lesion was 3.2 ± 1.3 cm and median reduction in SUV of the tumor among was -8.1 ± 5.4 and was statistically significant when compared with nonresponders ( P < 0.001). CT scan has 66% accuracy and PET has 82% accuracy at post three cycles NACT in predicting the pathological response. PET/CT had higher sensitivity and specificity when compared with CT findings alone in response evaluation. Conclusion: PET/CT scan can be considered as a sensitive tool for predicting pCRs and further larger trials are required to establish these findings. Competing Interests: There are no conflicts of interest. (Copyright: © 2020 Indian Journal of Nuclear Medicine.)
Databáze:	MEDLINE
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