Sleep neurophysiology in childhood onset schizophrenia.

Autor: Markovic A; University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.; Graduate School for Health Sciences, University of Bern, Bern, Switzerland., Buckley A; National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland., Driver DI; Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland., Dillard-Broadnax D; Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland., Gochman PA; Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland., Hoedlmoser K; Laboratory for Sleep, Cognition and Consciousness Research, Department of Psychology, Centre for Cognitive Neuroscience, University of Salzburg, Salzburg, Austria., Rapoport JL; Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland., Tarokh L; University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Jazyk: angličtina
Zdroj: Journal of sleep research [J Sleep Res] 2021 Apr; Vol. 30 (2), pp. e13039. Date of Electronic Publication: 2020 Apr 30.
DOI: 10.1111/jsr.13039
Abstrakt: Altered sleep neurophysiology has consistently been reported in adult patients with schizophrenia. Converging evidence suggests that childhood onset schizophrenia (COS), a rare but severe form of schizophrenia, is continuous with adult onset schizophrenia. The aim of the current study was to characterize sleep neurophysiology in COS. An overnight sleep electroencephalogram (EEG) was recorded in 17 children and adolescents with COS (16 years ± 6.6) and 17 age and gender-matched controls. Non-rapid eye movement (NREM) and rapid eye movement (REM) sleep EEG power and coherence for the frequency bands delta (1.6-4.8 Hz), theta (5-8.4 Hz), alpha (8.6-11 Hz), beta 1 (16.4-20.2 Hz) and beta 2 (20.4-24.2 Hz) were compared between COS patients and controls. COS patients exhibited significant and widespread deficits in beta power during NREM and REM sleep. With regard to coherence, we found increases in COS patients across brain regions, frequency bands and sleep states. This study demonstrates the utility of the sleep EEG for studying vulnerable populations and its potential to aid diagnosis.
(© 2020 European Sleep Research Society.)
Databáze: MEDLINE
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