Practical Comparison of the BioFire FilmArray Pneumonia Panel to Routine Diagnostic Methods and Potential Impact on Antimicrobial Stewardship in Adult Hospitalized Patients with Lower Respiratory Tract Infections.
| Autor: | Buchan BW; The Medical College of Wisconsin, Milwaukee, Wisconsin, USA bbuchan@mcw.edu., Windham S; The Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Balada-Llasat JM; The Ohio State University, Columbus, Ohio, USA., Leber A; Nationwide Children's Hospital, Columbus, Ohio, USA., Harrington A; Loyola University Medical Center, Maywood, Illinois, USA., Relich R; Indiana University School of Medicine, Indianapolis, Indiana, USA., Murphy C; University of Nebraska Medical Center, Omaha, Nebraska, USA., Dien Bard J; Children's Hospital of Los Angeles, Los Angeles, California, USA., Naccache S; Children's Hospital of Los Angeles, Los Angeles, California, USA., Ronen S; The Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Hopp A; The Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Mahmutoglu D; The Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Faron ML; The Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Ledeboer NA; The Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Carroll A; The Ohio State University, Columbus, Ohio, USA., Stone H; The Ohio State University, Columbus, Ohio, USA., Akerele O; The Ohio State University, Columbus, Ohio, USA., Everhart K; Nationwide Children's Hospital, Columbus, Ohio, USA., Bonwit A; Loyola University Medical Center, Maywood, Illinois, USA., Kwong C; Loyola University Medical Center, Maywood, Illinois, USA., Buckner R; Indiana University School of Medicine, Indianapolis, Indiana, USA., Warren D; Indiana University School of Medicine, Indianapolis, Indiana, USA., Fowler R; University of Nebraska Medical Center, Omaha, Nebraska, USA., Chandrasekaran S; University of California Los Angeles, Los Angeles, California, USA., Huse H; University of California Los Angeles, Los Angeles, California, USA., Campeau S; University of California Los Angeles, Los Angeles, California, USA., Humphries R; University of California Los Angeles, Los Angeles, California, USA., Graue C; BioFire Diagnostics, LLC, Salt Lake City, Utah, USA., Huang A; The Medical College of Wisconsin, Milwaukee, Wisconsin, USA.; Froedtert Hospital, Milwaukee, Wisconsin, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of clinical microbiology [J Clin Microbiol] 2020 Jun 24; Vol. 58 (7). Date of Electronic Publication: 2020 Jun 24 (Print Publication: 2020). |
| DOI: | 10.1128/JCM.00135-20 |
| Abstrakt: | Lower respiratory tract infections, including hospital-acquired and ventilator-associated pneumonia, are common in hospitalized patient populations. Standard methods frequently fail to identify the infectious etiology due to the polymicrobial nature of respiratory specimens and the necessity of ordering specific tests to identify viral agents. The potential severity of these infections combined with a failure to clearly identify the causative pathogen results in administration of empirical antibiotic agents based on clinical presentation and other risk factors. We examined the impact of the multiplexed, semiquantitative BioFire FilmArray Pneumonia panel (PN panel) test on laboratory reporting for 259 adult inpatients submitting bronchoalveolar lavage (BAL) specimens for laboratory analysis. The PN panel demonstrated a combined 96.2% positive percent agreement (PPA) and 98.1% negative percent agreement (NPA) for the qualitative identification of 15 bacterial targets compared to routine bacterial culture. Semiquantitative values reported by the PN panel were frequently higher than values reported by culture, resulting in semiquantitative agreement (within the same log (Copyright © 2020 Buchan et al.) |
| Databáze: | MEDLINE |
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