Spatial spread and emergence of reassortant H5 highly pathogenic avian influenza viruses in Iran.

Autor: Abdollahi H; National Reference Laboratory, Diagnosis & Applied Studies Center, Iran Veterinary Organization, Tehran Province, Iran., Maken Ali AS; Iran Veterinary Organization, Tehran Province, Iran., Monne I; EU/OIE/National Reference Laboratory for Avian Influenza and Newcastle Disease, FAO Reference Centre for Animal Influenza and Newcastle Disease, Istituto Zooprofilattico Sperimentale delle Venezie, viale dell'università 10, 35020 Legnaro, Padova, Italy., Milani A; EU/OIE/National Reference Laboratory for Avian Influenza and Newcastle Disease, FAO Reference Centre for Animal Influenza and Newcastle Disease, Istituto Zooprofilattico Sperimentale delle Venezie, viale dell'università 10, 35020 Legnaro, Padova, Italy., Habibi M; National Reference Laboratory, Diagnosis & Applied Studies Center, Iran Veterinary Organization, Tehran Province, Iran., Zamperin G; EU/OIE/National Reference Laboratory for Avian Influenza and Newcastle Disease, FAO Reference Centre for Animal Influenza and Newcastle Disease, Istituto Zooprofilattico Sperimentale delle Venezie, viale dell'università 10, 35020 Legnaro, Padova, Italy., Ghafouri SA; Iran Veterinary Organization, Tehran Province, Iran., Maghsoudloo H; National Reference Laboratory, Diagnosis & Applied Studies Center, Iran Veterinary Organization, Tehran Province, Iran., Mohammadpoor B; National Reference Laboratory, Diagnosis & Applied Studies Center, Iran Veterinary Organization, Tehran Province, Iran., Esmaeilzadeh S; National Reference Laboratory, Diagnosis & Applied Studies Center, Iran Veterinary Organization, Tehran Province, Iran., Farahani RK; Iran Veterinary Organization, Tehran Province, Iran., Ghasemi Y; National Reference Laboratory, Diagnosis & Applied Studies Center, Iran Veterinary Organization, Tehran Province, Iran., Afzalkhani AA; National Reference Laboratory, Diagnosis & Applied Studies Center, Iran Veterinary Organization, Tehran Province, Iran., Nabipoor J; National Reference Laboratory, Diagnosis & Applied Studies Center, Iran Veterinary Organization, Tehran Province, Iran., Javanmardi B; National Reference Laboratory, Diagnosis & Applied Studies Center, Iran Veterinary Organization, Tehran Province, Iran., Fusaro A; EU/OIE/National Reference Laboratory for Avian Influenza and Newcastle Disease, FAO Reference Centre for Animal Influenza and Newcastle Disease, Istituto Zooprofilattico Sperimentale delle Venezie, viale dell'università 10, 35020 Legnaro, Padova, Italy., Zecchin B; EU/OIE/National Reference Laboratory for Avian Influenza and Newcastle Disease, FAO Reference Centre for Animal Influenza and Newcastle Disease, Istituto Zooprofilattico Sperimentale delle Venezie, viale dell'università 10, 35020 Legnaro, Padova, Italy. Electronic address: bzecchin@izsvenezie.it.
Jazyk: angličtina
Zdroj: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2020 Sep; Vol. 83, pp. 104342. Date of Electronic Publication: 2020 Apr 27.
DOI: 10.1016/j.meegid.2020.104342
Abstrakt: Since 2005, H5Nx highly pathogenic avian influenza (HPAI) viruses of the Goose/Guangdong (Gs/GD) lineage have spread worldwide, affecting poultry and wild birds in Asia, Europe, Africa and North America. So far, the role of Western Asia and the Middle East in the diffusion dynamics of this virus has been poorly explored. In order to investigate the genetic diversity and the role of Iran in the transmission dynamics of the Gs/GD lineage, we sequenced the complete genome of twenty-eight H5Nx viruses which were circulating in the country between 2016 and 2018. We reported the first characterization of the HPAI H5N6 subtype of clade 2.3.4.4B in Iran and gave evidence of the high propensity of the Gs/GD H5 AIVs to reassort, describing six novel H5N8 genotypes of clade 2.3.4.4B, some of them likely generated in this area, and one H5N1 reassortant virus of clade 2.3.2.1c. Our spatial analyses demonstrated that the viruses resulted from different viral introductions from Asia and Europe and provided evidence of virus spread from Iran to the Middle East. Therefore, Iran may represent a hot-spot for virus introduction, dissemination and for the generation of new genetic variability. Increasing surveillance efforts in this high-risk area is of utmost importance for the early detection of novel emerging strains with zoonotic potential.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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