Reproducibility of whole-brain temperature mapping and metabolite quantification using proton magnetic resonance spectroscopy.

Autor: Zhang Y; Department of Psychology, University of Alabama at Birmingham, Alabama, US.; Department of Neurosurgery and Core for Advanced MRI, Baylor College of Medicine, Houston, Texas, US., Taub E; Department of Psychology, University of Alabama at Birmingham, Alabama, US., Mueller C; Department of Psychology, University of Alabama at Birmingham, Alabama, US., Younger J; Department of Psychology, University of Alabama at Birmingham, Alabama, US., Uswatte G; Department of Psychology, University of Alabama at Birmingham, Alabama, US.; Department of Physical Therapy, University of Alabama at Birmingham, Alabama, US., DeRamus TP; TReNDs Center for Translational Research in Neuroimaging and Data Science, Georgia, US.; Department of Psychology, Georgia State University, Georgia, US., Knight DC; Department of Psychology, University of Alabama at Birmingham, Alabama, US.
Jazyk: angličtina
Zdroj: NMR in biomedicine [NMR Biomed] 2020 Jul; Vol. 33 (7), pp. e4313. Date of Electronic Publication: 2020 Apr 29.
DOI: 10.1002/nbm.4313
Abstrakt: Assessing brain temperature can provide important information about disease processes (e.g., stroke, trauma) and therapeutic effects (e.g., cerebral hypothermia treatment). Whole-brain magnetic resonance spectroscopic imaging (WB-MRSI) is increasingly used to quantify brain metabolites across the entire brain. However, its feasibility and reliability for estimating brain temperature needs further validation. Therefore, the present study evaluates the reproducibility of WB-MRSI for temperature mapping as well as metabolite quantification across the whole brain in healthy volunteers. Ten healthy adults were scanned on three occasions 1 week apart. Brain temperature, along with four commonly assessed brain metabolites-total N-acetyl-aspartate (tNAA), total creatine (tCr), total choline (tCho) and myo-inositol (mI)-were measured from WB-MRSI data. Reproducibility was evaluated using the coefficient of variation (CV). The measured mean (range) of the intra-subject CVs was 0.9% (0.6%-1.6%) for brain temperature mapping, and 4.7% (2.5%-15.7%), 6.4% (2.4%-18.9%) and 14.2% (4.4%-52.6%) for tNAA, tCho and mI, respectively, with reference to tCr. Consistently larger variability was found when using H 2 O as the reference for metabolite quantifications: 7.8% (3.3%-17.8%), 7.8% (3.1%-18.0%), 9.8% (3.7%-31.0%) and 17.0% (5.9%-54.0%) for tNAA, tCr, tCho and mI, respectively. Further, the larger the brain region (indicated by a greater number of voxels within that region), the better the reproducibility for both temperature and metabolite estimates. Our results demonstrate good reproducibility of whole-brain temperature and metabolite measurements using the WB-MRSI technique.
(© 2020 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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