| Autor: |
Fetterman JL; Evans Department of Medicine and Whitaker Cardiovascular Institute Boston University School of Medicine Boston MA., Keith RJ; University of Louisville School of Medicine Louisville KY., Palmisano JN; Evans Department of Medicine and Whitaker Cardiovascular Institute Boston University School of Medicine Boston MA., McGlasson KL; Evans Department of Medicine and Whitaker Cardiovascular Institute Boston University School of Medicine Boston MA., Weisbrod RM; Evans Department of Medicine and Whitaker Cardiovascular Institute Boston University School of Medicine Boston MA., Majid S; Evans Department of Medicine and Whitaker Cardiovascular Institute Boston University School of Medicine Boston MA., Bastin R; Evans Department of Medicine and Whitaker Cardiovascular Institute Boston University School of Medicine Boston MA., Stathos MM; Evans Department of Medicine and Whitaker Cardiovascular Institute Boston University School of Medicine Boston MA., Stokes AC; School of Public Health Boston University Boston MA., Robertson RM; American Heart Association Dallas TX., Bhatnagar A; University of Louisville School of Medicine Louisville KY., Hamburg NM; Evans Department of Medicine and Whitaker Cardiovascular Institute Boston University School of Medicine Boston MA. |
| Abstrakt: |
Background Electronic cigarettes (e-cigarettes) have been proposed as a potential harm reduction tool for combustible cigarette smokers. The majority of adult e-cigarette users continue to smoke combustible cigarettes and are considered dual users. The vascular impact of e-cigarettes remains incompletely defined. Methods and Results We examined the association of e-cigarette use with measures of vascular function and tonometry, preclinical measures of cardiovascular injury. As part of the CITU (Cardiovascular Injury due to Tobacco Use) study, we performed noninvasive vascular function testing in individuals without known cardiovascular disease or cardiovascular disease risk factors who were nonsmokers (n=94), users of combustible cigarettes (n=285), users of e-cigarettes (n=36), or dual users (n=52). In unadjusted analyses, measures of arterial stiffness including carotid-femoral pulse wave velocity, augmentation index, carotid-radial pulse wave velocity, and central blood pressures differed across the use groups. In multivariable models adjusted for age, sex, race, and study site, combustible cigarette smokers had higher augmentation index compared with nonusers (129.8±1.5 versus 118.8±2.7, P =0.003). The augmentation index was similar between combustible cigarette smokers compared with sole e-cigarette users (129.8±1.5 versus 126.2±5.9, P =1.0) and dual users (129.8±1.5 versus 134.9±4.0, P =1.0). Endothelial cells from combustible cigarette smokers and sole e-cigarette users produced less nitric oxide in response to A23187 stimulation compared with nonsmokers, suggestive of impaired endothelial nitric oxide synthase signaling. Conclusions Our findings suggest that e-cigarette use is not associated with a more favorable vascular profile. Future longitudinal studies are needed to evaluate the long-term risks of sustained e-cigarette use. |
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