Influence of Natural Polyphenols on Isolated Yeast Dipodascus magnusii Mitochondria.

Autor: Dergacheva DI; Bach Institute of Biochemistry, Federal Research Center 'Fundamental Principles of Biotechnology', Russian Academy of Sciences, Moscow, Russia., Klein OI; Bach Institute of Biochemistry, Federal Research Center 'Fundamental Principles of Biotechnology', Russian Academy of Sciences, Moscow, Russia., Gessler NN; Bach Institute of Biochemistry, Federal Research Center 'Fundamental Principles of Biotechnology', Russian Academy of Sciences, Moscow, Russia., Isakova EP; Bach Institute of Biochemistry, Federal Research Center 'Fundamental Principles of Biotechnology', Russian Academy of Sciences, Moscow, Russia., Deryabina YI; Bach Institute of Biochemistry, Federal Research Center 'Fundamental Principles of Biotechnology', Russian Academy of Sciences, Moscow, Russia. yul_der@mail.ru., Nikolaev AV; Schmidt Institute of Physics of the Earth, Russian Academy of Sciences, Moscow, Russia.
Jazyk: angličtina
Zdroj: Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2020 Jan; Vol. 490 (1), pp. 12-15. Date of Electronic Publication: 2020 Apr 27.
DOI: 10.1134/S1607672920010044
Abstrakt: The effect of stilbene polyphenols (resveratrol and pinosilvin) and flavonoids (dihydromyricetin, epigallocatechin, and dihydroquercetin) on producing the reactive oxygen species (ROS) due to cell respiration using the isolated mitochondria of the fungus Dipodascus (Endomyces) magnusii was studied. It was shown that the inhibition of the ROS generation with stilbenes is related to both the oxygen consumption inhibition and their antioxidant properties. The degree of manifestation of polyphenol antioxidant properties depended on the number of hydroxyl groups in a polyphenol molecule. Of the flavonoids tested, dihydromyricetin was most active in reducing the ROS generation, but its inhibitory effect on oxygen consumption by mitochondria was significantly lower as compared to that of the stilbenes. The data obtained show that the mechanism of reducing the ROS generation with polyphenols is associated with both the respiratory inhibition and their antioxidant properties.
Databáze: MEDLINE
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