| Autor: |
Agahozo MC; Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands. m.agahozo@erasmusmc.nl., Westenend PJ; Laboratory for Pathology Dordrecht, Dordrecht, The Netherlands., van Bockstal MR; Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.; Cliniques universitaires Saint-Luc, Brussels, Belgium., Hansum T; Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Giang J; Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., Matlung SE; Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands., van Deurzen CHM; Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands. |
| Jazyk: |
angličtina |
| Zdroj: |
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc [Mod Pathol] 2020 Sep; Vol. 33 (9), pp. 1773-1782. Date of Electronic Publication: 2020 Apr 27. |
| DOI: |
10.1038/s41379-020-0553-9 |
| Abstrakt: |
Ductal carcinoma in situ (DCIS) associated stromal changes and influx of immune cells might be mediators of progression to invasive breast cancer. We studied the interaction between DCIS-associated stromal changes, and immune cell distribution and composition in a well-characterized patient cohort. We included 472 patients with DCIS. The presence of stromal changes, signs of regression, and DCIS-associated immune cell position were determined on hematoxylin and eosin-stained slides. Immune cell composition was characterized by immunohistochemistry (CD4, CD8, CD20, CD68, and FOXP3). The number of intraductal immune cells was quantified per mm 2 . The interaction between stromal changes, signs of DCIS regression, immune cell composition and location was explored. Stromal changes and signs of DCIS regression were identified in 30 and 7% of the patients, respectively. Intraductal immune cells mainly comprised CD68+ macrophages and CD8+ T cells. Patients with stromal changes had significantly less influx of immune cells within the duct. DCIS regression was associated with an increased number of intraductal FOXP3+ T cells. The highest number of intraductal CD8+ T cells was seen in the ER+ HER2+ subtype. We suggest that DCIS-associated stromal changes prevent the interaction between immune cells and DCIS cells. However, in case of DCIS regression, we surmise a direct interaction between DCIS cells and immune cells, in particular FOXP3+ cells. Furthermore, the increased number of intraductal CD8+ T cells in the ER+ HER2+ DCIS subtype suggests a subtype-specific immune response, which is likely to play a role in the distinct biological behavior of different DCIS subtypes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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