Indoor incense burning impacts cognitive functions and brain functional connectivity in community older adults.

Autor: Wong A; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.; Therese Pei Fong Chow Research Centre for Prevention of Dementia, The Chinese University of Hong Kong, Hong Kong SAR, China., Lou W; Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong SAR, China., Ho KF; The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China., Yiu BK; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China., Lin S; Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong SAR, China., Chu WC; Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong SAR, China., Abrigo J; Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong SAR, China., Lee D; Stony Brook University School of Medicine, Stony Brook, New York, United States., Lam BY; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.; Therese Pei Fong Chow Research Centre for Prevention of Dementia, The Chinese University of Hong Kong, Hong Kong SAR, China., Au LW; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.; Therese Pei Fong Chow Research Centre for Prevention of Dementia, The Chinese University of Hong Kong, Hong Kong SAR, China.; Gerald Choa Neuroscience Centre, Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China., Soo YO; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China., Lau AY; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China., Kwok TC; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.; Therese Pei Fong Chow Research Centre for Prevention of Dementia, The Chinese University of Hong Kong, Hong Kong SAR, China., Leung TW; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China., Lam LC; Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China., Ho K; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.; Gerald Choa Neuroscience Centre, Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China., Mok VC; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China. vctmok@cuhk.edu.hk.; Therese Pei Fong Chow Research Centre for Prevention of Dementia, The Chinese University of Hong Kong, Hong Kong SAR, China. vctmok@cuhk.edu.hk.; Gerald Choa Neuroscience Centre, Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China. vctmok@cuhk.edu.hk.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2020 Apr 27; Vol. 10 (1), pp. 7090. Date of Electronic Publication: 2020 Apr 27.
DOI: 10.1038/s41598-020-63568-6
Abstrakt: To investigate (1) the effects of indoor incense burning upon cognition over 3 years; (2) the associations between indoor incense burning with the brain's structure and functional connectivity of the default mode network (DMN); and (3) the interactions between indoor incense burning and vascular disease markers upon cognitive functions. Community older adults without stroke or dementia were recruited (n = 515). Indoor incense use was self-reported as having burnt incense at home ≥ weekly basis over the past 5 years. Detailed neuropsychological battery was administered at baseline (n = 227) and the Montreal Cognitive Assessment at baseline and year 3 (n = 515). MRI structural measures and functional connectivity of the DMN were recorded at baseline. Demographic and vascular risk factors and levels of outdoor pollutants were treated as covariates. Indoor incense burning was associated with reduced performance across multiple cognitive domains at baseline and year 3 as well as decreased connectivity in the DMN. It interacted with diabetes mellitus, hyperlipidemia and white matter hyperintensities to predict poorer cognitive performance. Indoor incense burning is (1) associated with poorer cognitive performance over 3 years; (2) related to decreased brain connectivity; and (3) it interacts with vascular disease to predispose poor cognitive performance.
Databáze: MEDLINE
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