| Autor: |
Alhmoud JF; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Al-Ahliyya Amman University, Amman 19328, Jordan., Woolley JF; Department of Molecular & Clinical Pharmacology, Liverpool University, Liverpool L69 3GE, UK., Al Moustafa AE; College of Medicine, QU Health, Qatar University, Doha P. O. Box 2713, Qatar., Malki MI; College of Medicine, QU Health, Qatar University, Doha P. O. Box 2713, Qatar. |
| Abstrakt: |
DNA damage is well recognized as a critical factor in cancer development and progression. DNA lesions create an abnormal nucleotide or nucleotide fragment, causing a break in one or both chains of the DNA strand. When DNA damage occurs, the possibility of generated mutations increases. Genomic instability is one of the most important factors that lead to cancer development. DNA repair pathways perform the essential role of correcting the DNA lesions that occur from DNA damaging agents or carcinogens, thus maintaining genomic stability. Inefficient DNA repair is a critical driving force behind cancer establishment, progression and evolution. A thorough understanding of DNA repair mechanisms in cancer will allow for better therapeutic intervention. In this review we will discuss the relationship between DNA damage/repair mechanisms and cancer, and how we can target these pathways. |
