Testis-specific serine kinase protein family in male fertility and as targets for non-hormonal male contraception†.

Autor:	Salicioni AM; Department of Veterinary and Animal Sciences, University of Massachusetts-Amherst, Integrated Sciences Building 427S, 661 North Pleasant Street, Amherst MA 01003, USA.; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, USA., Gervasi MG; Department of Veterinary and Animal Sciences, University of Massachusetts-Amherst, Integrated Sciences Building 427S, 661 North Pleasant Street, Amherst MA 01003, USA., Sosnik J; Department of Biology, University of Massachusetts, Boston, MA, USA., Tourzani DA; Department of Veterinary and Animal Sciences, University of Massachusetts-Amherst, Integrated Sciences Building 427S, 661 North Pleasant Street, Amherst MA 01003, USA.; Biotechnology Training Program, University of Massachusetts, Amherst, MA, USA., Nayyab S; Department of Veterinary and Animal Sciences, University of Massachusetts-Amherst, Integrated Sciences Building 427S, 661 North Pleasant Street, Amherst MA 01003, USA.; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, USA., Caraballo DA; IFIBYNE-CONICET, Department of Physiology, Molecular and Cellular Biology, University of Buenos Aires, Buenos Aires, Argentina., Visconti PE; Department of Veterinary and Animal Sciences, University of Massachusetts-Amherst, Integrated Sciences Building 427S, 661 North Pleasant Street, Amherst MA 01003, USA.; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, USA.
Jazyk:	angličtina
Zdroj:	Biology of reproduction [Biol Reprod] 2020 Aug 04; Vol. 103 (2), pp. 264-274.
DOI:	10.1093/biolre/ioaa064
Abstrakt:	Male contraception is a very active area of research. Several hormonal agents have entered clinical trials, while potential non-hormonal targets have been brought to light more recently and are at earlier stages of development. The general strategy is to target genes along the molecular pathways of sperm production, maturation, or function, and it is predicted that these novel approaches will hopefully lead to more selective male contraceptive compounds with a decreased side effect burden. Protein kinases are known to play a major role in signaling events associated with sperm differentiation and function. In this review, we focus our analysis on the testis-specific serine kinase (TSSK) protein family. We have previously shown that members of the family of TSSKs are postmeiotically expressed in male germ cells and in mature mammalian sperm. The restricted postmeiotic expression of TSSKs as well as the importance of phosphorylation in signaling processes strongly suggests that TSSKs have an important role in germ cell differentiation and/or sperm function. This prediction has been supported by the reported sterile phenotype of the Tssk6 knockout (KO) mice and of the double Tssk1 and Tssk2 KO mice and by the male subfertile phenotype observed in a Tssk4 KO mouse model. (© The Author(s) 2020. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu