Prevalence and incidence of, and risk factors for chronic cough in the adult population: the Rotterdam Study.

Autor:	Arinze JT; Dept of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands., de Roos EW; Dept of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.; Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Karimi L; Dept of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands., Verhamme KMC; Dept of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands., Stricker BH; Dept of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands., Brusselle GG; Dept of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.; Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.; Dept of Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	ERJ open research [ERJ Open Res] 2020 Apr 19; Vol. 6 (2). Date of Electronic Publication: 2020 Apr 19 (Print Publication: 2020).
DOI:	10.1183/23120541.00300-2019
Abstrakt:	Chronic cough is a common complaint in the general population but there are no precise data on the incidence of, and prospectively examined risk factors for chronic cough in a population-based setting. Therefore, we investigated the period prevalence, incidence and risk factors for chronic cough in adult subjects. In a prospective population-based cohort study among subjects aged ≥45 years, data on chronic cough were collected on two separate occasions using a standardised questionnaire. Chronic cough was defined as daily coughing for at least 3 months duration during the preceding 2 years. Potential risk factors were gathered by interview, physical examination and several investigations. Of the 9824 participants in this study, 1073 (10.9%) subjects had chronic cough at baseline. The prevalence of chronic cough increased with age and peaked in the eighth decade. In subjects aged <70 years, chronic cough was more common in women. During an average follow-up of 6 years, 439 incident cases of chronic cough occurred with an overall incidence rate of 11.6 per 1000 person-years (95% CI 10.6-12.8). In current smokers, the incidence of chronic cough was higher in men. In the multivariable analysis, current smoking, gastro-oesophageal reflux disease (GORD), asthma and COPD were identified as risk factors for chronic cough. Chronic cough is common among adults and highly prevalent in the older population. Current smoking, GORD, asthma and COPD are independent risk factors for chronic cough. Individuals at risk of developing chronic cough may benefit from smoking cessation and control of the underlying disease. Competing Interests: Conflict of interest: J.T. Arinze has nothing to disclose. Conflict of interest: E.W. de Roos has nothing to disclose. Conflict of interest: L. Karimi has nothing to disclose. Conflict of interest: K.M.C. Verhamme works for a research group that, in the past, received unconditional grants from Yamanouchi, Pfizer/Boehringer Ingelheim, Novartis and GSK, none of which relate to the content of this work. Conflict of interest: B.H. Stricker has nothing to disclose. Conflict of interest: G.G. Brusselle reports advisory boards and speaker's fees from AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Novartis and Teva; and advisory board fees from Sanofi, outside the submitted work. (Copyright ©ERS 2020.)
Databáze:	MEDLINE
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