Plasma cytokine profile in synucleinophaties with dementia.

Autor: Usenko TS; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre, «Kurchatov Institute», Gatchina, Russia; Pavlov First Saint Petersburg State Medical University, Saint-Petersburg, Russia. Electronic address: usenko_ts@pnpi.nrcki.ru., Nikolaev MA; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre, «Kurchatov Institute», Gatchina, Russia; Pavlov First Saint Petersburg State Medical University, Saint-Petersburg, Russia., Miliukhina IV; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre, «Kurchatov Institute», Gatchina, Russia; Pavlov First Saint Petersburg State Medical University, Saint-Petersburg, Russia; Institute of Experimental Medicine, Saint-Petersburg, Russia., Bezrukova AI; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre, «Kurchatov Institute», Gatchina, Russia., Senkevich KA; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre, «Kurchatov Institute», Gatchina, Russia; Pavlov First Saint Petersburg State Medical University, Saint-Petersburg, Russia; Institute of Experimental Medicine, Saint-Petersburg, Russia., Gomzyakova NA; V.M. Bekhterevs National Medical Research Center Psychiatry and Neurology, Saint-Petersburg, Russia., Beltceva YA; V.M. Bekhterevs National Medical Research Center Psychiatry and Neurology, Saint-Petersburg, Russia., Zalutskaya NM; V.M. Bekhterevs National Medical Research Center Psychiatry and Neurology, Saint-Petersburg, Russia., Gracheva EV; Institute of Experimental Medicine, Saint-Petersburg, Russia., Timofeeva AA; Pavlov First Saint Petersburg State Medical University, Saint-Petersburg, Russia., Petrova OA; Pavlov First Saint Petersburg State Medical University, Saint-Petersburg, Russia; Saint-Petersburg Pasteur Institute, Saint-Petersburg, Russia., Semenov AV; Pavlov First Saint Petersburg State Medical University, Saint-Petersburg, Russia; Saint-Petersburg Pasteur Institute, Saint-Petersburg, Russia., Lubimova NE; Saint-Petersburg Pasteur Institute, Saint-Petersburg, Russia., Totolyan AA; Pavlov First Saint Petersburg State Medical University, Saint-Petersburg, Russia; Saint-Petersburg Pasteur Institute, Saint-Petersburg, Russia., Pchelina SN; Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre, «Kurchatov Institute», Gatchina, Russia; Pavlov First Saint Petersburg State Medical University, Saint-Petersburg, Russia; Institute of Experimental Medicine, Saint-Petersburg, Russia.
Jazyk: angličtina
Zdroj: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2020 Aug; Vol. 78, pp. 323-326. Date of Electronic Publication: 2020 Apr 23.
DOI: 10.1016/j.jocn.2020.04.058
Abstrakt: Immune response may play a pivotal role in the pathogenesis of the common synucleinopathy as Parkinson's disease (PD) and could be mediated with the accumulation of neurotoxic alpha-synuclein. There is limited evidence for immune response in another synucleinopathy as dementia with Lewy bodies (DLB). Recent data suggest that immune response may contribute to cognitive impairment. We aimed to estimate plasma cytokine profile in patients with synucleinopathies with dementia (PD dementia (PDD), DLB). Plasma cytokine levels (interferon-gamma (IFN-gamma), interleukin (IL)-4 (IL-4), IL-6, IL-10, tumor necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1)). were estimated in 16 patients with DLB, 19 patients with PDD, 28 patients with PD without dementia (PD) and 19 individuals without neurological disorders (controls) using Luminex array system. Cognitive status was assessed with the Mini-Mental State Examination (MMSE). TNF-alpha and IL-6 plasma levels were elevated in patients with synucleinopathies with dementia (DLB, PDD) compared to controls and IL-10 plasma level was increased in PDD compared to controls (p < 0.05). IFN-gamma levels were decreased in PD and PDD patients compared to controls (p < 0.001, p = 0.026, respectively) and in PD patients than in DLB patients (p = 0.032). Patients with PD, PDD, and DLB were characterized by increased plasma levels of MCP-1 compared to controls (p < 0.001). At the same time, no differences in TNF-alpha, IL-10, IL-6 plasma levels in PD patients compared to controls were found. Our study demonstrated more pronounced immune response in synucleinopathies associated with dementia compared to PD without demetia.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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