Association of Dickkopf-1 Polymorphisms With Radiological Damage and Periodontal Disease in Patients With Early Rheumatoid Arthritis: A Cross-Sectional Study.

Autor:	Cardona-Rincón AD; From the Rheumatology and Immunology Department, Clinical Immunology Group School of Medicine, Hospital Militar Central/Universidad Militar Nueva Granada., Acevedo-Godoy MA, Bello-Gualtero JM; From the Rheumatology and Immunology Department, Clinical Immunology Group School of Medicine, Hospital Militar Central/Universidad Militar Nueva Granada., Valle-Oñate R; From the Rheumatology and Immunology Department, Clinical Immunology Group School of Medicine, Hospital Militar Central/Universidad Militar Nueva Granada., Chalem-Choueka P; Fundación Instituto de Reumatología Fernando Chalem., Perdomo SJ; School of Dentistry, Cellular, and Molecular Immunology Group/INMUBO Bogotá, Universidad El Bosque., Miyared Arias-Arias A; Health Faculty, Bacteriology Program, Universidad Colegio Mayor de Cundinamarca, Bogotá, Colombia., Chila-Moreno L, Bautista-Molano W, Romero-Sánchez C
Jazyk:	angličtina
Zdroj:	Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases [J Clin Rheumatol] 2020 Oct; Vol. 26 (7S Suppl 2), pp. S187-S194.
DOI:	10.1097/RHU.0000000000001391
Abstrakt:	Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease that increased bone resorption. Periodontal disease (PD) is an associated risk factor of RA. Studies suggest an association between bone markers such as the dickkopf-related protein 1 (DKK-1) and progression of radiological damage. We aimed to evaluate the marker DKK-1, its polymorphisms in patients with early rheumatoid arthritis (eRA), and its association with rheumatic, radiological, and periodontal variables. Methods: This is a cross-sectional study. Samples were obtained from 63 patients with eRA. Radiographs of hands and feet were evaluated by Sharp-van der Heijde score (SHS) and Simple Erosion Narrowing Score (SENS). Serum DKK-1 levels and high-resolution fusion analysis was used for polymorphisms (rs1896368, rs1896367, rs1528873). Bivariate analyses were performed. Results: Individuals heterozygous for rs1896367 had more frequent erosions (p = 0.026) and joint space narrowing (p = 0.005) in the feet, higher SHS (p = 0.016), and higher SENS (p ≤ 0.001). Patients homozygous for rs1896368 had less frequent joint space narrowing in hands and feet as assessed by SHS and less presence of erosions by SENS (odds ratio, 0.04; 95% confidence interval, 0.00-0.93; p < 0.05). The presence of PD was associated with the homozygous of rs1896367 (p = 0.009) and the heterozygous of rs1896368 (p = 0.033). Conclusions: Polymorphism rs1896367 seems to be associated with greater radiological compromise; rs1896368 confers protection against bone damage in Colombian eRA patients.
Databáze:	MEDLINE
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