The relationship between physical activity, apolipoprotein E ε4 carriage, and brain health.

Autor: de Frutos-Lucas J; Biological and Health Psychology Department, School of Psychology, Universidad Autonoma de Madrid, 28049, Madrid, Spain. jaisalmer.defrutos@ctb.upm.es.; Laboratory of Cognitive and Computational Neuroscience (UCM-UPM), Center for biomedical Technology, Parque Científico y Tecnológico de la UPM, Crta. M40, Km. 38, 28223, Pozuelo de Alarcón, Madrid, Spain. jaisalmer.defrutos@ctb.upm.es.; Collaborative Genomics Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, 6027, Australia. jaisalmer.defrutos@ctb.upm.es., Cuesta P; Laboratory of Cognitive and Computational Neuroscience (UCM-UPM), Center for biomedical Technology, Parque Científico y Tecnológico de la UPM, Crta. M40, Km. 38, 28223, Pozuelo de Alarcón, Madrid, Spain.; Department of Industrial Engineering & IUNE, Universidad de La Laguna, 38200, San Cristobal de la Laguna, Tenerife, Spain., López-Sanz D; Laboratory of Cognitive and Computational Neuroscience (UCM-UPM), Center for biomedical Technology, Parque Científico y Tecnológico de la UPM, Crta. M40, Km. 38, 28223, Pozuelo de Alarcón, Madrid, Spain.; Department of Psychobiology and Methodology in Behavioral Sciences, School of Education, Universidad Complutense de Madrid, 28040, Madrid, Spain., Peral-Suárez Á; Departamento de Nutricion y Ciencia de los Alimentos, Facultad de Farmacia, Universidad Complutense de Madrid, 28040, Madrid, Spain., Cuadrado-Soto E; Departamento de Nutricion y Ciencia de los Alimentos, Facultad de Farmacia, Universidad Complutense de Madrid, 28040, Madrid, Spain., Ramírez-Toraño F; Laboratory of Cognitive and Computational Neuroscience (UCM-UPM), Center for biomedical Technology, Parque Científico y Tecnológico de la UPM, Crta. M40, Km. 38, 28223, Pozuelo de Alarcón, Madrid, Spain.; Experimental Psychology Department, School of Psychology, Universidad Complutense de Madrid, 28223, Pozuelo de Alarcon, Spain., Brown BM; Discipline of Exercise Science, College of Science, Health, Engineering and Education, Murdoch University, Murdoch, Western Australia, 6150, Australia., Serrano JM; Biological and Health Psychology Department, School of Psychology, Universidad Autonoma de Madrid, 28049, Madrid, Spain., Laws SM; Collaborative Genomics Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, 6027, Australia.; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, 6102, Australia., Rodríguez-Rojo IC; Laboratory of Cognitive and Computational Neuroscience (UCM-UPM), Center for biomedical Technology, Parque Científico y Tecnológico de la UPM, Crta. M40, Km. 38, 28223, Pozuelo de Alarcón, Madrid, Spain.; Centro Universitario Villanueva, Facultad de Psicología, 28034, Madrid, Spain., Verdejo-Román J; Laboratory of Cognitive and Computational Neuroscience (UCM-UPM), Center for biomedical Technology, Parque Científico y Tecnológico de la UPM, Crta. M40, Km. 38, 28223, Pozuelo de Alarcón, Madrid, Spain.; Experimental Psychology Department, School of Psychology, Universidad Complutense de Madrid, 28223, Pozuelo de Alarcon, Spain.; Mind, Brain and Behavior Research Center (CIMCYC), Universidad de Granada, 18071, Granada, Spain., Bruña R; Laboratory of Cognitive and Computational Neuroscience (UCM-UPM), Center for biomedical Technology, Parque Científico y Tecnológico de la UPM, Crta. M40, Km. 38, 28223, Pozuelo de Alarcón, Madrid, Spain.; Experimental Psychology Department, School of Psychology, Universidad Complutense de Madrid, 28223, Pozuelo de Alarcon, Spain.; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029, Madrid, Spain., Delgado-Losada ML; Experimental Psychology Department, School of Psychology, Universidad Complutense de Madrid, 28223, Pozuelo de Alarcon, Spain., Barabash A; Endocrinology and Nutrition Department, Hospital Clinico San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, 28040, Madrid, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, 28040, Madrid, Spain., López-Sobaler AM; Departamento de Nutricion y Ciencia de los Alimentos, Facultad de Farmacia, Universidad Complutense de Madrid, 28040, Madrid, Spain., López-Higes R; Experimental Psychology Department, School of Psychology, Universidad Complutense de Madrid, 28223, Pozuelo de Alarcon, Spain., Marcos A; Neurology Department, Hospital Clinico San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, 28040, Madrid, Spain., Maestú F; Laboratory of Cognitive and Computational Neuroscience (UCM-UPM), Center for biomedical Technology, Parque Científico y Tecnológico de la UPM, Crta. M40, Km. 38, 28223, Pozuelo de Alarcón, Madrid, Spain.; Experimental Psychology Department, School of Psychology, Universidad Complutense de Madrid, 28223, Pozuelo de Alarcon, Spain.; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029, Madrid, Spain.
Jazyk: angličtina
Zdroj: Alzheimer's research & therapy [Alzheimers Res Ther] 2020 Apr 24; Vol. 12 (1), pp. 48. Date of Electronic Publication: 2020 Apr 24.
DOI: 10.1186/s13195-020-00608-3
Abstrakt: Background: Neuronal hyperexcitability and hypersynchrony have been described as key features of neurophysiological dysfunctions in the Alzheimer's disease (AD) continuum. Conversely, physical activity (PA) has been associated with improved brain health and reduced AD risk. However, there is controversy regarding whether AD genetic risk (in terms of APOE ε4 carriage) modulates these relationships. The utilization of multiple outcome measures within one sample may strengthen our understanding of this complex phenomenon.
Method: The relationship between PA and functional connectivity (FC) was examined in a sample of 107 healthy older adults using magnetoencephalography. Additionally, we explored whether ε4 carriage modulates this association. The correlation between FC and brain structural integrity, cognition, and mood was also investigated.
Results: A relationship between higher PA and decreased FC (hyposynchrony) in the left temporal lobe was observed among all individuals (across the whole sample, in ε4 carriers, and in ε4 non-carriers), but its effects manifest differently according to genetic risk. In ε4 carriers, we report an association between this region-specific FC profile and preserved brain structure (greater gray matter volumes and higher integrity of white matter tracts). In this group, decreased FC also correlated with reduced anxiety levels. In ε4 non-carriers, this profile is associated with improved cognition (working and episodic memory).
Conclusions: PA could mitigate the increase in FC (hypersynchronization) that characterizes preclinical AD, being beneficial for all individuals, especially ε4 carriers.
Databáze: MEDLINE
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