Opportunities in the Synthesis and Design of Radioactive Thin Films and Nanoparticles.

Autor: Coughlin BP; Department of Chemistry, Tufts University, Medford, Massachusetts 02155, United States., Mace CR; Department of Chemistry, Tufts University, Medford, Massachusetts 02155, United States., Sykes ECH; Department of Chemistry, Tufts University, Medford, Massachusetts 02155, United States.
Jazyk: angličtina
Zdroj: The journal of physical chemistry letters [J Phys Chem Lett] 2020 May 21; Vol. 11 (10), pp. 4017-4028. Date of Electronic Publication: 2020 May 06.
DOI: 10.1021/acs.jpclett.0c00412
Abstrakt: Studies of radioactive isotopes at the liquid-solid or gas-solid interface are enabling a detailed mechanistic understanding of the effects of radioactive decay on physical, biological, and chemical systems. In recent years, there has been a burgeoning interest in using radioactive isotopes for both imaging and therapeutic purposes by attaching them to the surface of colloidal nanoparticles. By merging the field of nanomedicine with the more mature field of internal radiation therapy, researchers are discovering new ways to diagnose and treat cancer. In this Perspective, we discuss state-of-the-art radioactive thin films as applied to both well-defined surfaces and more complex nanoparticles. We highlight the design considerations that are unique to radioactive films, which originate from the damaging and potentially self-destructive emissions produced during radioactive decay, and highlight future opportunities in the largely underexplored area between radioisotope chemistry and nanoscience.
Databáze: MEDLINE