| Autor: |
Revathi N; Department of Chemistry, Ramco Institute of Technology, Virudhunagar, Tamil Nadu, India.; Department of Chemistry, Manonmanium Sundaranar University, Tirunelveli, Tamil Nadu, India., Sankarganesh M; Department of Chemistry, K. Ramakrishnan College of Technology, Trichy, Tamil Nadu, India., Dhaveethu Raja J; Department of Chemistry, The American College, Madurai, Tamil Nadu, India., Vinoth Kumar GG; Department of Chemistry, Sethu Institute of Technology, Virudhunagar, Tamil Nadu, India., Sakthivel A; Department of Chemistry, Mepco Schlenk Engineering College, Sivakasi, Tamil Nadu, India., Rajasekaran R; Department of Biomedical Sciences, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India. |
| Abstrakt: |
A new series of bio active Cu(II) and Zn(II) complexes [CuL(phen)](OOCCH 3 ) ( 1 ), [ZnL(phen)](OOCCH 3 ) ( 2 ), [CuL(bpy)](OOCCH 3 ) ( 3 ), [ZnL(bpy)](OOCCH 3 ) ( 4 ) have been synthesized using the pyrimidine derivative Schiff base ( HL ) [ HL = 2-(4,6-dimethylpyrimidin-2-ylimino)methyl)-4-nitrophenol], 1,10-phenanthroline (phen), 2,2'-bipyridine (bpy) and acetate salts of Cu(II) and Zn(II). UV-Visible, FT-IR, 1 H-NMR, ESR, elemental analysis, molar conductance and EI-MS spectral techniques have been used to endorse the square planar geometry for the complexes 1 - 4 . The optimized molecular structure and the harmonic vibrational frequencies have been scrutinized by DFT methods. The antibacterial and antifungal activity of Schiff base ( HL ) and complexes 1 - 4 indicates that complex 1 acts as good antimicrobial agent against microbial strains than HL , complexes 2 - 4 and standard drugs streptomycin and nystatin. DNA cleavage study of the complexes 1 - 4 exposes that complexes 1 and 3 spectacle good cleaving agent than complexes 2 and 4 . The interaction of complexes 1 - 4 with CT DNA using absorption, emission and viscometric measurements signifies that complexes 1 - 4 bind via an intercalation mode. The highest binding constants ( K b ) for the complex 1 is confirmed as 7.83 × 10 3 M -1 and 2.98 × 10 4 M -1 by absorption and emission spectrum respectively. These experimental observations were found to be close to the theoretical observations investigated by the molecular docking technique. Antioxidant property of the complexes 1 - 4 using DPPH assay clinches that complex 1 produces significant scavenging effect than other compounds. The result of in vitro cytotoxicity of the Schiff base ( HL ) and complexes 1 - 4 shows that complex 1 shows better ability to inhibit the growth of cancer cells. Communicated by Ramaswamy H. Sarma. |
