Recent advances in domesticating non-model microorganisms.

Autor: Fatma Z; Department of Chemical and Biomolecular Engineering, Carl R. Woese Institute for Genomic Biology , University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., Schultz JC; Department of Chemical and Biomolecular Engineering, Carl R. Woese Institute for Genomic Biology , University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., Zhao H; Department of Chemical and Biomolecular Engineering, Carl R. Woese Institute for Genomic Biology , University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Departments of Chemistry, Biochemistry, and Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Jazyk: angličtina
Zdroj: Biotechnology progress [Biotechnol Prog] 2020 Sep; Vol. 36 (5), pp. e3008. Date of Electronic Publication: 2020 May 12.
DOI: 10.1002/btpr.3008
Abstrakt: Non-model microorganisms have been increasingly explored as microbial cell factories for production of chemicals, fuels, and materials owing to their unique physiology and metabolic capabilities. However, these microorganisms often lack facile genetic tools for strain development, which hinders their adoption as production hosts. In this review, we describe recent advances in domestication of non-model microorganisms, including bacteria, actinobacteria, cyanobacteria, yeast, and fungi, with a focus on the development of genetic tools. In addition, we highlight some successful applications of non-model microorganisms as microbial cell factories.
(© 2020 American Institute of Chemical Engineers.)
Databáze: MEDLINE
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