The Dementias Platform UK (DPUK) Data Portal.

Autor: Bauermeister S; Department of Psychiatry, University of Oxford, Oxford, UK., Orton C; Swansea University Medical School, Swansea University, Swansea, UK., Thompson S; Swansea University Medical School, Swansea University, Swansea, UK., Barker RA; Cambridge University Department of Clinical Neurosciences and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Bauermeister JR; Department of Psychiatry, University of Oxford, Oxford, UK., Ben-Shlomo Y; Population Health Sciences, University of Bristol, Bristol, UK., Brayne C; Department of Public Health, University of Cambridge, Cambridge, UK., Burn D; Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Campbell A; Department of Medical Genetics, University of Edinburgh, Edinburgh, UK., Calvin C; Department of Psychiatry, University of Oxford, Oxford, UK., Chandran S; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Chaturvedi N; MRC Unit for Lifelong Health and Ageing, UCL, London, UK., Chêne G; Bordeaux Population Health, Université Bordeaux, Bordeaux, France., Chessell IP; Neuroscience BioPharma R&D, AstraZeneca, Cambridge, UK., Corbett A; College of Medicine and Health, University of Exeter, Exeter, UK., Davis DHJ; MRC Unit for Lifelong Health and Ageing, UCL, London, UK., Denis M; Oxford Academic Health Science Network, University of Oxford, Oxford, UK., Dufouil C; Bordeaux Population Health, Université Bordeaux, Bordeaux, France., Elliott P; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Imperial College NIHR Biomedical Research Centre, Imperial College London, London, UK.; Health Data Research UK London at Imperial College London, London, UK., Fox N; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Hill D; King's College London, London, UK., Hofer SM; Department of Psychology, University of Victoria, Victoria, Canada., Hu MT; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Jindra C; Department of Psychiatry, University of Oxford, Oxford, UK., Kee F; Centre for Public Health, Queen's University Belfast, Belfast, UK., Kim CH; Department of Psychiatry, University of Oxford, Oxford, UK., Kim C; Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, South Korea., Kivimaki M; Institute of Epidemiology and Health, University College London, London, UK., Koychev I; Department of Psychiatry, University of Oxford, Oxford, UK., Lawson RA; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Linden GJ; Centre for Public Health, Queen's University Belfast, Belfast, UK., Lyons RA; Swansea University Medical School, Swansea University, Swansea, UK., Mackay C; Department of Psychiatry, University of Oxford, Oxford, UK., Matthews PM; Division of Brain Sciences and UK Dementia Research Institute, Imperial College London, London, UK., McGuiness B; Centre for Public Health, Queen's University Belfast, Belfast, UK., Middleton L; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Moody C; Medical Research Council, Swindon, UK., Moore K; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Na DL; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea., O'Brien JT; Department of Psychiatry, University of Cambridge, Cambridge, UK., Ourselin S; School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK., Paranjothy S; School of Medicine, Cardiff University, Cardiff, UK., Park KS; Institute of Health Science, Gyeongsang National University, Jinju-si, South Korea., Porteous DJ; Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Richards M; MRC Unit for Lifelong Health and Ageing, UCL, London, UK., Ritchie CW; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Rohrer JD; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Rossor MN; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Rowe JB; Cambridge University Department of Clinical Neurosciences and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Scahill R; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Schnier C; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Schott JM; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Seo SW; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea., South M; Department of Psychiatry, University of Oxford, Oxford, UK., Steptoe M; Department of Behavioural Science and Health, UCL, London, UK., Tabrizi SJ; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Tales A; Centre for Innovative Ageing, Swansea University, Swansea, UK., Tillin T; UCL Institute for Cardiovascular Science, London, UK., Timpson NJ; Population Health Sciences, University of Bristol, Bristol, UK., Toga AW; Laboratory of Neuro Imaging, USC, Los Angeles, USA., Visser PJ; VU University Medical Centre, Maastricht University, Maastricht, The Netherlands., Wade-Martins R; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Wilkinson T; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Williams J; Institute of Psychological Medicine and Clinical Neurosciences, and UK Dementia Research Institute, Cardiff University, Cardiff, UK., Wong A; MRC Unit for Lifelong Health and Ageing, UCL, London, UK., Gallacher JEJ; Department of Psychiatry, University of Oxford, Oxford, UK. john.gallacher@psych.ox.ac.uk.
Jazyk: angličtina
Zdroj: European journal of epidemiology [Eur J Epidemiol] 2020 Jun; Vol. 35 (6), pp. 601-611. Date of Electronic Publication: 2020 Apr 23.
DOI: 10.1007/s10654-020-00633-4
Abstrakt: The Dementias Platform UK Data Portal is a data repository facilitating access to data for 3 370 929 individuals in 42 cohorts. The Data Portal is an end-to-end data management solution providing a secure, fully auditable, remote access environment for the analysis of cohort data. All projects utilising the data are by default collaborations with the cohort research teams generating the data. The Data Portal uses UK Secure eResearch Platform infrastructure to provide three core utilities: data discovery, access, and analysis. These are delivered using a 7 layered architecture comprising: data ingestion, data curation, platform interoperability, data discovery, access brokerage, data analysis and knowledge preservation. Automated, streamlined, and standardised procedures reduce the administrative burden for all stakeholders, particularly for requests involving multiple independent datasets, where a single request may be forwarded to multiple data controllers. Researchers are provided with their own secure 'lab' using VMware which is accessed using two factor authentication. Over the last 2 years, 160 project proposals involving 579 individual cohort data access requests were received. These were received from 268 applicants spanning 72 institutions (56 academic, 13 commercial, 3 government) in 16 countries with 84 requests involving multiple cohorts. Projects are varied including multi-modal, machine learning, and Mendelian randomisation analyses. Data access is usually free at point of use although a small number of cohorts require a data access fee.
Databáze: MEDLINE