| Autor: |
Toma L; Lipidomics Department, Institute of Cellular Biology and Pathology 'Nicolae Simionescu' of the Romanian Academy, 8, B.P. Hasdeu Street, 050568 Bucharest, Romania., Sanda GM; Lipidomics Department, Institute of Cellular Biology and Pathology 'Nicolae Simionescu' of the Romanian Academy, 8, B.P. Hasdeu Street, 050568 Bucharest, Romania., Niculescu LS; Lipidomics Department, Institute of Cellular Biology and Pathology 'Nicolae Simionescu' of the Romanian Academy, 8, B.P. Hasdeu Street, 050568 Bucharest, Romania., Deleanu M; Lipidomics Department, Institute of Cellular Biology and Pathology 'Nicolae Simionescu' of the Romanian Academy, 8, B.P. Hasdeu Street, 050568 Bucharest, Romania.; Faculty of Biotechnology, University of Agronomical Sciences and Veterinary Medicine, 59, Marasti Blvd., 011464 Bucharest, Romania., Sima AV; Lipidomics Department, Institute of Cellular Biology and Pathology 'Nicolae Simionescu' of the Romanian Academy, 8, B.P. Hasdeu Street, 050568 Bucharest, Romania., Stancu CS; Lipidomics Department, Institute of Cellular Biology and Pathology 'Nicolae Simionescu' of the Romanian Academy, 8, B.P. Hasdeu Street, 050568 Bucharest, Romania. |
| Abstrakt: |
Atherosclerosis is the main process behind cardiovascular diseases (CVD), maladies which continue to be responsible for up to 70% of death worldwide. Despite the ongoing development of new and potent drugs, their incomplete efficacy, partial intolerance and numerous side effects make the search for new alternatives worthwhile. The focus of the scientific world turned to the potential of natural active compounds to prevent and treat CVD. Essential for effective prevention or treatment based on phytochemicals is to know their mechanisms of action according to their bioavailability and dosage. The present review is focused on the latest data about phenolic compounds and aims to collect and correlate the reliable existing knowledge concerning their molecular mechanisms of action to counteract important risk factors that contribute to the initiation and development of atherosclerosis: dyslipidemia, and oxidative and inflammatory-stress. The selection of phenolic compounds was made to prove their multiple benefic effects and endorse them as CVD remedies, complementary to allopathic drugs. The review also highlights some aspects that still need clear scientific explanations and draws up some new molecular approaches to validate phenolic compounds for CVD complementary therapy in the near future. |
