Where Is Bacosine in Commercially Available Bacopa monnieri?

Autor:	Ritter S; Organic-analytical Chemistry, Weihenstephan-Triesdorf University of Applied Sciences, Straubing, Germany.; Campus Straubing for Biotechnology and Sustainability, Technical University of Munich, Straubing, Germany., Urmann C; Organic-analytical Chemistry, Weihenstephan-Triesdorf University of Applied Sciences, Straubing, Germany.; Campus Straubing for Biotechnology and Sustainability, Technical University of Munich, Straubing, Germany., Herzog R; Organic-analytical Chemistry, Weihenstephan-Triesdorf University of Applied Sciences, Straubing, Germany.; Campus Straubing for Biotechnology and Sustainability, Technical University of Munich, Straubing, Germany., Glaser J; PhytoLab GmbH & Co. KG, Vestenbergsgreuth, Germany., Bieringer S; Organic-analytical Chemistry, Weihenstephan-Triesdorf University of Applied Sciences, Straubing, Germany.; Campus Straubing for Biotechnology and Sustainability, Technical University of Munich, Straubing, Germany., Geisberger T; Department of Chemistry, Technical University of Munich, Garching, Germany., Eisenreich W; Department of Chemistry, Technical University of Munich, Garching, Germany., Riepl H; Organic-analytical Chemistry, Weihenstephan-Triesdorf University of Applied Sciences, Straubing, Germany.; Campus Straubing for Biotechnology and Sustainability, Technical University of Munich, Straubing, Germany.
Jazyk:	angličtina
Zdroj:	Planta medica [Planta Med] 2020 May; Vol. 86 (8), pp. 565-570. Date of Electronic Publication: 2020 Apr 23.
DOI:	10.1055/a-1137-4289
Abstrakt:	Bacopa monnieri is an Ayurvedic plant with rising interest in the pharmacological effects of its extract and constituents, including flavonoids, saponins, and triterpenes such as cucurbitacins, betulinic acid, and bacosine. The latter two compounds are isomeric 3-hydroxy lupenoic acids, which vary only in the arrangement of the carboxylic acid group and the methyl group at C-27 and C-28 and the orientation of the hydroxy group at C-3. In this study, we have reinvestigated the contents of betulinic acid and bacosine, respectively, in extracts from various commercially available B. monnieri powders and food supplements. To our surprise, HPLC-ion trap time-of-flight analyses identified only betulinic acid, but not bacosine, in all extracts under study, which was verified by GC-MS, HPLC-ELSD, 1D NMR ( 1 H, 13 C), and 2D NMR ( 1 H, 1 H COSY, 1 H, 13 C HMBC, 1 H, 13 C HSQC, 1 H, 1 H NOESY) experiments. Moreover, it turned out that commercially available reference samples of bacosine were structurally identical with betulinic acid. Competing Interests: Dr. Jan Glaser, co-author of this publication, is working at PhytoLab GmbH & Co. KG. (Georg Thieme Verlag KG Stuttgart · New York.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu