Impaired motor cortical plasticity associated with cannabis use disorder in young adults.

Autor: Martin-Rodriguez JF; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.; Experimental Psychology Department, Faculty of Psychology, University of Seville, Seville, Spain., Ruiz-Veguilla M; CIBERSAM, Centro de Investigación Biomédica en Red Salud Mental, Madrid, Spain.; UGC-SALUD MENTAL, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla/UGC Salud Mental HVR, Seville, Spain., Alvarez de Toledo P; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain., Aizpurua-Olaizola O; Departamento de Química Analítica, Universidad del País Vasco (UPV/EHU), Leioa, Spain., Zarandona I; Departamento de Química Analítica, Universidad del País Vasco (UPV/EHU), Leioa, Spain., Canal-Rivero M; CIBERSAM, Centro de Investigación Biomédica en Red Salud Mental, Madrid, Spain.; Departamento de Psiquiatría, Hospital Universitario Germans Trías i Pujol, Badalona, Barcelona, Spain., Rodriguez-Baena A; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain., Mir P; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Jazyk: angličtina
Zdroj: Addiction biology [Addict Biol] 2021 May; Vol. 26 (3), pp. e12912. Date of Electronic Publication: 2020 Apr 23.
DOI: 10.1111/adb.12912
Abstrakt: Maladaptive cortical plasticity has been described in individuals with heroin and methamphetamine addiction and may mediate other substance abuse disorders. It is unknown whether cannabis dependence in humans alters the capacity for induction of cortical plasticity. The aim of this study was to non-invasively investigate cortical plasticity with transcranial magnetic stimulation in young adults who meet DSM-5 criteria for cannabis use disorder (CUD). Thirty men (ages 20- 30) who used cannabis daily over the previous 6 months (15 diagnosed of CUD) and 15 demographically matched non-users were enrolled in this study. All participants underwent two sessions of theta burst stimulation (TBS) in which either continuous TBS (cTBS; 600 pulses, 80% active motor threshold) or intermittent TBS (iTBS; 2-s train of cTBS repeated every 10 s for a total of 190 s, 600 pulses) was applied over the primary motor cortex. The effects of these protocols were assessed by analysing the contralateral motor evoked potentials (MEPs). The relationships between cortical plasticity and problematic cannabis use, degree of dependence, and nicotine addiction were also investigated. Significant MEP inhibition after cTBS was observed in both cannabis users without CUD and non-users, while this inhibition was not seen in cannabis users with CUD. Strikingly, less motor cortical plasticity was observed in subjects with severe problematic cannabis use. No significant differences between users and non-users were found in the iTBS-induced cortical plasticity measures. Our study provides the first evidence of maladaptive cortical plasticity associated with cannabis use disorder and problematic cannabis use in humans.
(© 2020 Society for the Study of Addiction.)
Databáze: MEDLINE
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